CDH5

Gene Information

Official Symbol: CDH5
Official Name: cadherin 5
Aliases and Previous Symbols: N/A
Entrez ID: 1003
UniProt: P33151
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. {ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:21269602}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13779
Expression level (log2 read counts): -1.16

Expression Distribution

Screen	Score
QNZ 0.01μM R08 exp439	-1.81
GW501516 25μM R06 exp285	2.01

Cadherin
Cadherin C

positive regulation of endothelial cell development
fibrinogen binding
positive regulation of establishment of endothelial barrier
vascular endothelial growth factor receptor 2 binding
blood vessel maturation
BMP receptor binding
negative regulation of microtubule polymerization
regulation of endothelial cell development
regulation of establishment of endothelial barrier
positive regulation of endothelial cell differentiation
regulation of establishment of cell polarity
regulation of establishment or maintenance of cell polarity
protein tyrosine kinase binding
cell-cell adhesion mediated by cadherin
catenin complex
positive regulation of BMP signaling pathway
regulation of endothelial cell differentiation
regulation of vascular permeability
negative regulation of microtubule polymerization or depolymerization
positive regulation of protein dephosphorylation
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
regulation of microtubule polymerization
positive regulation of dephosphorylation
positive regulation of epithelial cell differentiation
negative regulation of protein polymerization
cytoskeletal protein binding
regulation of microtubule polymerization or depolymerization
adherens junction organization
beta-catenin binding
protein phosphatase binding
regulation of BMP signaling pathway
transforming growth factor beta receptor signaling pathway
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cell-cell junction assembly
cell-cell adherens junction
bicellular tight junction
ion channel binding
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
anatomical structure maturation