CDIPT [The Human Chemical-Genetic Interaction Map Project]

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======= CDIPT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDIPT
  * **<color #00a2e8>Official Name</color>**: CDP-diacylglycerol--inositol 3-phosphatidyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10423|10423]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14735|O14735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDIPT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDIPT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605893|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDP-OH P transf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|
|alcohol binding|
|diacylglycerol binding|
|CDP-diacylglycerol metabolic process|
|pyrimidine nucleotide metabolic process|
|manganese ion binding|
|pyrimidine-containing compound metabolic process|
|phosphatidylinositol biosynthetic process|
|phosphatidylinositol metabolic process|
|carbohydrate binding|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|lipid biosynthetic process|
|Golgi membrane|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|lipid metabolic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-3.59|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.93|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-2.93|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|-2.87|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.76|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-2.74|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.71|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.65|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.63|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.62|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-2.47|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.44|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.38|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|-2.38|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.35|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-2.33|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-2.33|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.33|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.31|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.3|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.28|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.28|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.28|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.27|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.26|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.26|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.26|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-2.19|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-2.17|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.13|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.1|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.1|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2.09|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.09|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.09|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.08|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.07|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.07|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.07|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.07|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.06|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.06|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.06|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.03|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.03|
|[[:results:exp303|39°C R06 exp303]]|-2.02|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.02|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.95|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.95|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.94|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.94|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.92|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.92|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.89|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.88|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.88|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.87|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.86|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.86|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.86|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.85|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.84|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.84|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.84|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.82|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.82|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.8|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.8|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.78|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.78|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.78|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.77|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.76|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.75|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.74|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.71|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.7|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.81|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg1|ALG1]]|0.556|
|[[:human genes:d:dpagt1|DPAGT1]]|0.525|
|[[:human genes:h:hars|HARS]]|0.509|
|[[:human genes:r:rnmt|RNMT]]|0.505|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.486|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.478|
|[[:human genes:t:thg1l|THG1L]]|0.476|
|[[:human genes:c:ccdc115|CCDC115]]|0.473|
|[[:human genes:g:gnb1l|GNB1L]]|0.473|
|[[:human genes:p:pmm2|PMM2]]|0.471|
|[[:human genes:p:ppp4c|PPP4C]]|0.467|
|[[:human genes:s:snf8|SNF8]]|0.466|
|[[:human genes:t:tti2|TTI2]]|0.465|
|[[:human genes:s:srp14|SRP14]]|0.461|
|[[:human genes:r:rptor|RPTOR]]|0.452|
|[[:human genes:d:dhrsx|DHRSX]]|0.45|
|[[:human genes:u:uap1|UAP1]]|0.448|
|[[:human genes:m:med16|MED16]]|0.444|
|[[:human genes:r:rabggtb|RABGGTB]]|0.438|
|[[:human genes:a:alg13|ALG13]]|0.435|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.432|
|[[:human genes:a:alg5|ALG5]]|0.432|
|[[:human genes:b:bub3|BUB3]]|0.43|
|[[:human genes:r:rpp21|RPP21]]|0.43|
|[[:human genes:d:dolk|DOLK]]|0.429|
|[[:human genes:d:dad1|DAD1]]|0.428|
|[[:human genes:g:gemin8|GEMIN8]]|0.423|
|[[:human genes:g:gmppb|GMPPB]]|0.418|
|[[:human genes:n:nae1|NAE1]]|0.415|
|[[:human genes:t:tsen54|TSEN54]]|0.415|
|[[:human genes:r:rbm14|RBM14]]|0.415|
|[[:human genes:a:atxn10|ATXN10]]|0.413|
|[[:human genes:g:gfpt1|GFPT1]]|0.41|
|[[:human genes:t:tamm41|TAMM41]]|0.409|
|[[:human genes:a:alg2|ALG2]]|0.409|
|[[:human genes:b:bap1|BAP1]]|0.408|
|[[:human genes:u:utp23|UTP23]]|0.404|
|[[:human genes:a:adsl|ADSL]]|0.403|
|[[:human genes:t:triap1|TRIAP1]]|0.403|
|[[:human genes:d:dohh|DOHH]]|0.403|
|[[:human genes:d:dhps|DHPS]]|0.403|
|[[:human genes:u:ube2g2|UBE2G2]]|0.402|
|[[:human genes:v:vma21|VMA21]]|0.402|
|[[:human genes:h:hspd1|HSPD1]]|0.402|
|[[:human genes:d:ddx20|DDX20]]|0.401|
|[[:human genes:p:pam16|PAM16]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 507/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|19/28|
|bone|21/26|
|breast|23/33|
|central nervous system|43/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|12/21|
|liver|16/20|
|lung|56/75|
|lymphocyte|9/16|
|ovary|17/26|
|pancreas|17/24|
|peripheral nervous system|10/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|14/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 95
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDIPT Expression in NALM6 Cells: 4.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>