CDIPT
Gene Information
- Official Symbol: CDIPT
- Official Name: CDP-diacylglycerol–inositol 3-phosphatidyltransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 10423
- UniProt: O14735
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188}.
Pfam Domains GO Terms
Pfam Domains
| CDP-OH P transf |
GO Terms
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity |
| alcohol binding |
| diacylglycerol binding |
| CDP-diacylglycerol metabolic process |
| pyrimidine nucleotide metabolic process |
| manganese ion binding |
| pyrimidine-containing compound metabolic process |
| phosphatidylinositol biosynthetic process |
| phosphatidylinositol metabolic process |
| carbohydrate binding |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| phospholipid biosynthetic process |
| glycerophospholipid metabolic process |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| lipid biosynthetic process |
| Golgi membrane |
| organophosphate metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| Golgi apparatus |
| lipid metabolic process |
| small molecule metabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ALG1 | 0.556 |
| DPAGT1 | 0.525 |
| HARS | 0.509 |
| RNMT | 0.505 |
| GTF3C6 | 0.486 |
| GTF3C4 | 0.478 |
| THG1L | 0.476 |
| CCDC115 | 0.473 |
| GNB1L | 0.473 |
| PMM2 | 0.471 |
| PPP4C | 0.467 |
| SNF8 | 0.466 |
| TTI2 | 0.465 |
| SRP14 | 0.461 |
| RPTOR | 0.452 |
| DHRSX | 0.45 |
| UAP1 | 0.448 |
| MED16 | 0.444 |
| RABGGTB | 0.438 |
| ALG13 | 0.435 |
| GTF3C2 | 0.432 |
| ALG5 | 0.432 |
| BUB3 | 0.43 |
| RPP21 | 0.43 |
| DOLK | 0.429 |
| DAD1 | 0.428 |
| GEMIN8 | 0.423 |
| GMPPB | 0.418 |
| NAE1 | 0.415 |
| TSEN54 | 0.415 |
| RBM14 | 0.415 |
| ATXN10 | 0.413 |
| GFPT1 | 0.41 |
| TAMM41 | 0.409 |
| ALG2 | 0.409 |
| BAP1 | 0.408 |
| UTP23 | 0.404 |
| ADSL | 0.403 |
| TRIAP1 | 0.403 |
| DOHH | 0.403 |
| DHPS | 0.403 |
| UBE2G2 | 0.402 |
| VMA21 | 0.402 |
| HSPD1 | 0.402 |
| DDX20 | 0.401 |
| PAM16 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 507/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 15/28 |
| blood | 19/28 |
| bone | 21/26 |
| breast | 23/33 |
| central nervous system | 43/56 |
| cervix | 3/4 |
| colorectal | 8/17 |
| esophagus | 8/13 |
| fibroblast | 1/1 |
| gastric | 10/16 |
| kidney | 12/21 |
| liver | 16/20 |
| lung | 56/75 |
| lymphocyte | 9/16 |
| ovary | 17/26 |
| pancreas | 17/24 |
| peripheral nervous system | 10/16 |
| plasma cell | 3/15 |
| prostate | 0/1 |
| skin | 14/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 18/22 |
| urinary tract | 21/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 95
- Expression level (log2 read counts): 4.46
Expression Distribution
CDIPT Expression in NALM6 Cells: 4.46
