CDK10 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK10
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8558|8558]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15131|Q15131]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603464|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|traversing start control point of mitotic cell cycle|
|negative regulation of cilium assembly|
|negative regulation of plasma membrane bounded cell projection assembly|
|cyclin-dependent protein serine/threonine kinase activity|
|positive regulation of G1/S transition of mitotic cell cycle|
|negative regulation of organelle assembly|
|positive regulation of cell cycle G1/S phase transition|
|positive regulation of mitotic cell cycle phase transition|
|regulation of cilium assembly|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|positive regulation of cell cycle phase transition|
|ciliary basal body|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|negative regulation of cell projection organization|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|positive regulation of cell cycle process|
|regulation of actin cytoskeleton organization|
|protein serine/threonine kinase activity|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|regulation of actin filament-based process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|regulation of mitotic cell cycle|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of MAPK cascade|
|regulation of cell cycle process|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|protein phosphorylation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-3.56|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-3.35|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-3|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.92|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.87|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.72|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.85|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.89|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.96|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.23|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.75|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|3.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fam58a|FAM58A]]|0.681|
|[[:human genes:t:ttc14|TTC14]]|0.643|
|[[:human genes:c:ccnk|CCNK]]|0.434|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK10 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>