CDK10

Gene Information

Official Symbol: CDK10
Official Name: cyclin dependent kinase 10
Aliases and Previous Symbols: N/A
Entrez ID: 8558
UniProt: Q15131
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.225μM R08 exp444	-3.56
THZ531 0.11 to 0.125μM on day4 R07 exp410	-3.35
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-3
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.92
THZ531 0.11μM R07 exp409	-2.73
Aminopterin 0.005μM R07 exp335	-1.87
Methotrexate 0.01μM R08 exp501	-1.72
Vemurafenib 6.6μM R02 exp89	1.82
All-trans-Retinoic-Acid 40μM R07 exp334	1.85
Vemurafenib 6.6μM R08 exp434	1.89
TRAIL 5ng/ml R00 exp35	1.96
GSK626616 14μM R08 exp485	2.23
Trametinib 10μM R02 exp83	2.75
BI-D1870 3.15μM R02 exp66	3.35

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2602
Expression level (log2 read counts): 6.43

Expression Distribution

Gene	Correlation
FAM58A	0.681
TTC14	0.643
CCNK	0.434

Pkinase
Pkinase Tyr

traversing start control point of mitotic cell cycle
negative regulation of cilium assembly
negative regulation of plasma membrane bounded cell projection assembly
cyclin-dependent protein serine/threonine kinase activity
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of organelle assembly
positive regulation of cell cycle G1/S phase transition
positive regulation of mitotic cell cycle phase transition
regulation of cilium assembly
peptidyl-threonine phosphorylation
peptidyl-threonine modification
positive regulation of cell cycle phase transition
ciliary basal body
regulation of G1/S transition of mitotic cell cycle
positive regulation of mitotic cell cycle
regulation of cell cycle G1/S phase transition
negative regulation of cell projection organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
positive regulation of cell cycle process
regulation of actin cytoskeleton organization
protein serine/threonine kinase activity
negative regulation of organelle organization
positive regulation of cell cycle
regulation of actin filament-based process
regulation of mitotic cell cycle phase transition
regulation of cell cycle phase transition
regulation of cytoskeleton organization
positive regulation of MAPK cascade
regulation of mitotic cell cycle
negative regulation of cell population proliferation
regulation of plasma membrane bounded cell projection organization
negative regulation of cellular component organization
regulation of cell projection organization
regulation of MAPK cascade
regulation of cell cycle process
peptidyl-amino acid modification
regulation of cellular component biogenesis
protein phosphorylation