CDK13 [The Human Chemical-Genetic Interaction Map Project]

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======= CDK13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDK13
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8621|8621]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14004|Q14004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDK13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDK13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclin K-CDK13 complex|
|nuclear cyclin-dependent protein kinase holoenzyme complex|
|phosphorylation of RNA polymerase II C-terminal domain|
|cyclin/CDK positive transcription elongation factor complex|
|alternative mRNA splicing, via spliceosome|
|positive regulation of transcription elongation from RNA polymerase II promoter|
|RNA polymerase II CTD heptapeptide repeat kinase activity|
|negative regulation of stem cell differentiation|
|cyclin-dependent protein serine/threonine kinase activity|
|cyclin binding|
|cyclin-dependent protein kinase holoenzyme complex|
|regulation of transcription elongation from RNA polymerase II promoter|
|positive regulation of DNA-templated transcription, elongation|
|regulation of DNA-templated transcription, elongation|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|regulation of stem cell differentiation|
|chromosome|
|ficolin-1-rich granule lumen|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|transcription regulatory region DNA binding|
|nuclear chromatin|
|protein kinase activity|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|transcription factor binding|
|RNA splicing|
|nuclear speck|
|protein kinase binding|
|mRNA processing|
|transcription by RNA polymerase II|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|hemopoiesis|
|myeloid leukocyte activation|
|hematopoietic or lymphoid organ development|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|mRNA metabolic process|
|viral process|
|regulated exocytosis|
|negative regulation of cell differentiation|
|regulation of cell cycle process|
|leukocyte mediated immunity|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|RNA processing|
|positive regulation of cell population proliferation|
|leukocyte activation|
|negative regulation of developmental process|
|protein phosphorylation|
|Golgi apparatus|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|RNA binding|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|extracellular space|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.73|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.71|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.78|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.82|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.84|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.87|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.9|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.07|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.24|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|2.24|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.27|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.29|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.35|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.54|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.7|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.74|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|3.1|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gata3|GATA3]]|0.443|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 800
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDK13 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>