CDK13

Gene Information

Official Symbol: CDK13
Official Name: cyclin dependent kinase 13
Aliases and Previous Symbols: N/A
Entrez ID: 8621
UniProt: Q14004
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Thapsigargin 0.005μM R07 exp407	-1.73
Tubastatin-A 2.5μM R07 exp417	1.71
Vemurafenib 6.6μM R08 exp434	1.71
Taxol 0.004μM R03 exp103	1.72
Selumetinib 20μM R02 exp81	1.75
Sulforaphane 9μM R08 exp525	1.78
Cerivastatin 0.15μM R05 exp226	1.82
TRAIL 50ng/ml R00 exp36	1.84
BI-D1870 3.15μM R02 exp66	1.87
Demecolcine 0.03μM R05 exp228	1.9
Epothilone-B 0.0015μM R05 exp231	2.07
3-Bromopyruvate 7μM R04 exp175	2.24
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	2.24
Cabazitaxel 0.001μM R05 exp223	2.27
MK-1775 0.32μM R02 exp75	2.29
Aminopterin 0.005μM R07 exp335	2.35
Olaparib 4μM R08 exp512	2.54
Vemurafenib 6.6μM R02 exp89	2.7
Ribavirin 10 to 15μM on day4 R04 exp160	2.74
Diepoxybutane 3μM R07 exp354	3.1
I-BRD9 4μM R07 exp365	4.39

Global Fraction of Cell Lines Where Essential: 2/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 800
Expression level (log2 read counts): 6.45

Expression Distribution

Pkinase
Pkinase Tyr

cyclin K-CDK13 complex
nuclear cyclin-dependent protein kinase holoenzyme complex
phosphorylation of RNA polymerase II C-terminal domain
cyclin/CDK positive transcription elongation factor complex
alternative mRNA splicing, via spliceosome
positive regulation of transcription elongation from RNA polymerase II promoter
RNA polymerase II CTD heptapeptide repeat kinase activity
negative regulation of stem cell differentiation
cyclin-dependent protein serine/threonine kinase activity
cyclin binding
cyclin-dependent protein kinase holoenzyme complex
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, elongation
regulation of DNA-templated transcription, elongation
transcription elongation from RNA polymerase II promoter
DNA-templated transcription, elongation
regulation of stem cell differentiation
chromosome
ficolin-1-rich granule lumen
regulation of mitotic nuclear division
regulation of nuclear division
transcription regulatory region DNA binding
nuclear chromatin
protein kinase activity
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
transcription factor binding
RNA splicing
nuclear speck
protein kinase binding
mRNA processing
transcription by RNA polymerase II
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity