CDK5R1
Gene Information
- Official Symbol: CDK5R1
- Official Name: cyclin dependent kinase 5 regulatory subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8851
- UniProt: Q15078
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:24235147}.
Pfam Domains GO Terms
Pfam Domains
| CDK5 activator |
GO Terms
| superior olivary nucleus maturation |
| superior olivary nucleus development |
| protein kinase 5 complex |
| pons maturation |
| serine phosphorylation of STAT protein |
| contractile fiber |
| hindbrain maturation |
| central nervous system maturation |
| cyclin-dependent protein serine/threonine kinase activator activity |
| pons development |
| layer formation in cerebral cortex |
| neuron cell-cell adhesion |
| G protein-coupled acetylcholine receptor signaling pathway |
| cerebral cortex radial glia guided migration |
| telencephalon glial cell migration |
| axonal fasciculation |
| neuron projection fasciculation |
| ionotropic glutamate receptor signaling pathway |
| protein kinase activator activity |
| ephrin receptor binding |
| protein serine/threonine kinase activator activity |
| cerebral cortex radially oriented cell migration |
| positive regulation of microtubule polymerization |
| acetylcholine receptor signaling pathway |
| positive regulation of protein targeting to membrane |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| cellular response to acetylcholine |
| response to acetylcholine |
| ionotropic glutamate receptor binding |
| positive regulation of microtubule polymerization or depolymerization |
| positive regulation of cyclin-dependent protein kinase activity |
| glial cell migration |
| regulation of protein targeting to membrane |
| beta-tubulin binding |
| alpha-tubulin binding |
| postsynaptic signal transduction |
| negative regulation of axon extension |
| cerebral cortex cell migration |
| regulation of dendritic spine morphogenesis |
| glutamate receptor signaling pathway |
| neuron recognition |
| regulation of microtubule polymerization |
| positive regulation of neuron apoptotic process |
| telencephalon cell migration |
| forebrain cell migration |
| neural nucleus development |
| negative regulation of axonogenesis |
| regulation of dendritic spine development |
| neuromuscular junction |
| positive regulation of cell cycle arrest |
| regulation of microtubule polymerization or depolymerization |
| kinase activity |
| hippocampus development |
| regulation of protein targeting |
| peptidyl-threonine phosphorylation |
| ephrin receptor signaling pathway |
| peptidyl-threonine modification |
| regulation of dendrite morphogenesis |
| positive regulation of neuron death |
| signal transduction involved in cellular response to ammonium ion |
| presynapse |
| regulation of axon extension |
| regulation of postsynapse organization |
| negative regulation of cell morphogenesis involved in differentiation |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| protease binding |
| cerebellum development |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of developmental growth |
| regulation of cell cycle arrest |
| limbic system development |
| regulation of extent of cell growth |
| metencephalon development |
| regulation of synaptic vesicle cycle |
| cerebral cortex development |
| neuron migration |
| positive regulation of protein localization to membrane |
| positive regulation of protein polymerization |
| growth cone |
| regulation of receptor signaling pathway via JAK-STAT |
| cellular response to ammonium ion |
| regulation of receptor signaling pathway via STAT |
| anatomical structure maturation |
| dendritic spine |
| regulation of dendrite development |
| hindbrain development |
| negative regulation of neuron projection development |
| positive regulation of intracellular protein transport |
| regulation of macroautophagy |
| pallium development |
| peptidyl-serine phosphorylation |
| regulation of signal transduction by p53 class mediator |
| regulation of cell size |
| negative regulation of cell projection organization |
| negative regulation of cell growth |
| regulation of axonogenesis |
| response to ammonium ion |
| regulation of protein localization to membrane |
| regulation of microtubule cytoskeleton organization |
| positive regulation of supramolecular fiber organization |
| peptidyl-serine modification |
| actin filament binding |
| regulation of neuron apoptotic process |
| positive regulation of intracellular transport |
| gliogenesis |
| regulation of synapse organization |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| regulation of intracellular protein transport |
| cell recognition |
| protein kinase activity |
| developmental maturation |
| negative regulation of growth |
| positive regulation of protein complex assembly |
| postsynaptic density |
| telencephalon development |
| axon guidance |
| neuron projection guidance |
| rhythmic process |
| positive regulation of cell cycle process |
| negative regulation of neurogenesis |
| axon |
| regulation of cell morphogenesis involved in differentiation |
| cadherin binding |
| regulation of neuron death |
| negative regulation of nervous system development |
| neuron projection |
| positive regulation of cellular protein localization |
| activation of protein kinase activity |
| regulation of developmental growth |
| regulation of autophagy |
| negative regulation of cell development |
| positive regulation of protein serine/threonine kinase activity |
| regulation of actin cytoskeleton organization |
| regulation of intracellular transport |
| regulation of supramolecular fiber organization |
| neuronal cell body |
| axonogenesis |
| positive regulation of cell cycle |
| regulation of cellular component size |
| forebrain development |
| regulation of actin filament-based process |
| cellular response to drug |
| axon development |
| regulation of cell growth |
| dendrite |
| positive regulation of protein transport |
| cell morphogenesis involved in neuron differentiation |
| regulation of protein complex assembly |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| protein kinase binding |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell-cell adhesion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| regulation of anatomical structure size |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| regulation of cellular protein localization |
| regulation of cytoskeleton organization |
| chemotaxis |
| regulation of vesicle-mediated transport |
| taxis |
| cell morphogenesis involved in differentiation |
| positive regulation of kinase activity |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| regulation of neuron differentiation |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| regulation of growth |
| microtubule-based process |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| calcium ion binding |
| cell morphogenesis |
| regulation of peptide transport |
| brain development |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| head development |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| regulation of cellular localization |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| cell migration |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| central nervous system development |
| positive regulation of transport |
| regulation of catabolic process |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| cytoskeleton organization |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| cell development |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Alda-1 10μM R06 exp262 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9254
- Expression level (log2 read counts): 3.64
Expression Distribution
CDK5R1 Expression in NALM6 Cells: 3.64
