CDK5RAP1

Gene Information

Official Symbol: CDK5RAP1
Official Name: CDK5 regulatory subunit associated protein 1
Aliases and Previous Symbols: N/A
Entrez ID: 51654
UniProt: Q96SZ6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3323
Expression level (log2 read counts): 6.05

Expression Distribution

UPF0004
TRAM
Radical SAM

N6-isopentenyladenosine methylthiotransferase activity
tRNA methylthiolation
positive regulation of translational fidelity
mitochondrial tRNA modification
mitochondrial RNA modification
mitochondrial tRNA processing
tRNA threonylcarbamoyladenosine metabolic process
mitochondrial RNA processing
positive regulation of mitochondrial translation
regulation of translational fidelity
regulation of mitochondrial translation
regulation of mitochondrial gene expression
negative regulation of cyclin-dependent protein serine/threonine kinase activity
negative regulation of cyclin-dependent protein kinase activity
mitochondrial RNA metabolic process
4 iron, 4 sulfur cluster binding
tRNA modification
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of cyclin-dependent protein kinase activity
positive regulation of translation
tRNA processing
negative regulation of protein serine/threonine kinase activity
mitochondrial gene expression
positive regulation of cellular amide metabolic process
RNA modification
tRNA metabolic process
negative regulation of protein kinase activity
negative regulation of kinase activity
protein-containing complex binding
negative regulation of transferase activity
regulation of translation
ncRNA processing
regulation of cellular amide metabolic process
negative regulation of protein phosphorylation
negative regulation of phosphorylation
cellular component
protein kinase binding
ncRNA metabolic process
regulation of protein serine/threonine kinase activity
posttranscriptional regulation of gene expression