CDKL5 [The Human Chemical-Genetic Interaction Map Project]

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======= CDKL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDKL5
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6792|6792]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76039|O76039]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDKL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDKL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates phosphorylation of MECP2. {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic growth cone|
|postsynaptic density, intracellular component|
|cyclin-dependent protein serine/threonine kinase activity|
|dendrite cytoplasm|
|positive regulation of dendrite morphogenesis|
|positive regulation of dendritic spine development|
|positive regulation of axon extension|
|ciliary tip|
|Rac GTPase binding|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|kinase activity|
|regulation of cilium assembly|
|positive regulation of axonogenesis|
|regulation of dendrite morphogenesis|
|ruffle membrane|
|regulation of postsynapse organization|
|regulation of axon extension|
|regulation of extent of cell growth|
|neuron migration|
|ciliary basal body|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cell size|
|regulation of axonogenesis|
|protein autophosphorylation|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of synapse organization|
|regulation of organelle assembly|
|regulation of synapse structure or activity|
|protein kinase activity|
|positive regulation of growth|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|regulation of developmental growth|
|glutamatergic synapse|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|positive regulation of GTPase activity|
|regulation of cell growth|
|positive regulation of neurogenesis|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|centrosome|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.94|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18701
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDKL5 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>