CDKL5

• Official Symbol: CDKL5
• Official Name: cyclin dependent kinase like 5
• Aliases and Previous Symbols: N/A
• Entrez ID: 6792
• UniProt: O76039
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
• UniProt Summary: Mediates phosphorylation of MECP2. {ECO:0000269|PubMed:15917271, ECO:0000269|PubMed:16935860}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18701
• Expression level (log2 read counts): 4.51

Expression Distribution

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CDKL5 Expression in NALM6 Cells: 4.51