CDS1

Entrez Summary: N/A
UniProt Summary: Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

diacylglycerol cholinephosphotransferase activity
phosphatidate cytidylyltransferase activity
CDP-choline pathway
CDP-diacylglycerol biosynthetic process
CDP-diacylglycerol metabolic process
phosphatidylcholine biosynthetic process
phototransduction
pyrimidine nucleotide biosynthetic process
pyrimidine-containing compound biosynthetic process
detection of light stimulus
pyrimidine nucleotide metabolic process
phosphatidylcholine metabolic process
pyrimidine-containing compound metabolic process
phosphatidylinositol biosynthetic process
detection of external stimulus
detection of abiotic stimulus
phosphatidylinositol metabolic process
ammonium ion metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
nucleotide biosynthetic process
phospholipid biosynthetic process
nucleoside phosphate biosynthetic process
response to light stimulus
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
response to radiation
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
lipid biosynthetic process
detection of stimulus
organophosphate metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
nucleobase-containing compound biosynthetic process
response to abiotic stimulus