CDT1 [The Human Chemical-Genetic Interaction Map Project]

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======= CDT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CDT1
  * **<color #00a2e8>Official Name</color>**: chromatin licensing and DNA replication factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81620|81620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H211|Q9H211]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CDT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CDT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605525|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for both DNA replication and mitosis (PubMed:11125146, PubMed:22581055, PubMed:21856198, PubMed:14993212). DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre- RC)(PubMed:14672932). Required also for mitose by promoting stable kinetochore-microtubule attachments (PubMed:22581055). Potential oncogene (By similarity). {ECO:0000250|UniProtKB:Q8R4E9, ECO:0000269|PubMed:11125146, ECO:0000269|PubMed:14672932, ECO:0000269|PubMed:14993212, ECO:0000269|PubMed:21856198, ECO:0000269|PubMed:22581055}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDT1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deactivation of mitotic spindle assembly checkpoint|
|negative regulation of spindle checkpoint|
|negative regulation of protein localization to kinetochore|
|regulation of mediator complex assembly|
|positive regulation of mediator complex assembly|
|regulation of DNA replication origin binding|
|DNA replication preinitiation complex assembly|
|regulation of protein localization to kinetochore|
|positive regulation of protein localization to kinetochore|
|response to sorbitol|
|regulation of DNA-dependent DNA replication initiation|
|negative regulation of cell cycle checkpoint|
|positive regulation of mitotic metaphase/anaphase transition|
|positive regulation of mitotic sister chromatid separation|
|positive regulation of metaphase/anaphase transition of cell cycle|
|attachment of mitotic spindle microtubules to kinetochore|
|positive regulation of chromosome separation|
|positive regulation of DNA-dependent DNA replication|
|positive regulation of chromatin binding|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|regulation of mitotic spindle checkpoint|
|regulation of spindle checkpoint|
|DNA replication checkpoint|
|regulation of nuclear cell cycle DNA replication|
|positive regulation of mitotic sister chromatid segregation|
|kinetochore organization|
|DNA polymerase binding|
|attachment of spindle microtubules to kinetochore|
|regulation of chromatin binding|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|positive regulation of chromosome segregation|
|regulation of cell cycle checkpoint|
|positive regulation of DNA replication|
|nuclear DNA replication|
|mitotic metaphase plate congression|
|cell cycle DNA replication|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|positive regulation of mitotic nuclear division|
|regulation of DNA-dependent DNA replication|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|positive regulation of nuclear division|
|regulation of mitotic sister chromatid segregation|
|mitotic cytokinesis|
|establishment of chromosome localization|
|chromosome localization|
|positive regulation of mitotic cell cycle phase transition|
|regulation of sister chromatid segregation|
|kinetochore|
|condensed chromosome kinetochore|
|positive regulation of cell cycle phase transition|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|regulation of chromosome segregation|
|regulation of DNA replication|
|mitotic sister chromatid segregation|
|negative regulation of cellular protein localization|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|regulation of DNA binding|
|sister chromatid segregation|
|DNA integrity checkpoint|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|regulation of mitotic nuclear division|
|response to carbohydrate|
|positive regulation of chromosome organization|
|positive regulation of binding|
|regulation of nuclear division|
|cell cycle checkpoint|
|protein-DNA complex assembly|
|DNA replication|
|nuclear chromosome segregation|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|mitotic cell cycle phase transition|
|chromosome segregation|
|cell cycle phase transition|
|nuclear body|
|nuclear division|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|organelle fission|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|establishment of organelle localization|
|regulation of binding|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|cell division|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|cell cycle process|
|regulation of protein localization|
|chromosome organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|DNA binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.75|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.24|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.1|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.09|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.93|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.91|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.89|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.86|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.86|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.78|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.72|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.7|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.7|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.73|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.77|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.79|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.79|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.82|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.85|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.86|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.93|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.11|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|2.18|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.53|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|3.05|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.572|
|[[:human genes:p:psmb4|PSMB4]]|0.521|
|[[:human genes:n:nop16|NOP16]]|0.479|
|[[:human genes:r:rfc1|RFC1]]|0.47|
|[[:human genes:z:zfand5|ZFAND5]]|0.469|
|[[:human genes:r:rpl35|RPL35]]|0.468|
|[[:human genes:p:psmd11|PSMD11]]|0.466|
|[[:human genes:r:rps2|RPS2]]|0.465|
|[[:human genes:c:chd4|CHD4]]|0.46|
|[[:human genes:d:ddtl|DDTL]]|0.456|
|[[:human genes:c:ccna2|CCNA2]]|0.456|
|[[:human genes:e:exosc5|EXOSC5]]|0.453|
|[[:human genes:c:chmp4b|CHMP4B]]|0.452|
|[[:human genes:p:psma6|PSMA6]]|0.451|
|[[:human genes:r:rrm1|RRM1]]|0.447|
|[[:human genes:r:rps12|RPS12]]|0.443|
|[[:human genes:x:xylt2|XYLT2]]|0.443|
|[[:human genes:z:znf830|ZNF830]]|0.443|
|[[:human genes:i:ik|IK]]|0.443|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:e:exosc9|EXOSC9]]|0.438|
|[[:human genes:m:mt1e|MT1E]]|0.437|
|[[:human genes:o:orc6|ORC6]]|0.436|
|[[:human genes:p:pan2|PAN2]]|0.435|
|[[:human genes:i:igfn1|IGFN1]]|0.434|
|[[:human genes:p:psmd1|PSMD1]]|0.433|
|[[:human genes:g:gosr2|GOSR2]]|0.432|
|[[:human genes:u:utp3|UTP3]]|0.432|
|[[:human genes:p:psma1|PSMA1]]|0.43|
|[[:human genes:n:npipb5|NPIPB5]]|0.43|
|[[:human genes:r:rrn3|RRN3]]|0.428|
|[[:human genes:d:dhx38|DHX38]]|0.427|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.427|
|[[:human genes:d:dtl|DTL]]|0.425|
|[[:human genes:p:prpf19|PRPF19]]|0.425|
|[[:human genes:c:cdc73|CDC73]]|0.424|
|[[:human genes:s:sf3a3|SF3A3]]|0.423|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.423|
|[[:human genes:p:ppm1d|PPM1D]]|0.423|
|[[:human genes:p:polr2h|POLR2H]]|0.42|
|[[:human genes:e:exosc3|EXOSC3]]|0.416|
|[[:human genes:r:rps19|RPS19]]|0.416|
|[[:human genes:c:col2a1|COL2A1]]|0.414|
|[[:human genes:p:psmc2|PSMC2]]|0.413|
|[[:human genes:p:psmb1|PSMB1]]|0.413|
|[[:human genes:n:narfl|NARFL]]|0.413|
|[[:human genes:p:pan3|PAN3]]|0.411|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.411|
|[[:human genes:d:ddx56|DDX56]]|0.411|
|[[:human genes:s:supt6h|SUPT6H]]|0.41|
|[[:human genes:n:nupl1|NUPL1]]|0.41|
|[[:human genes:p:psmc1|PSMC1]]|0.41|
|[[:human genes:c:chmp2a|CHMP2A]]|0.41|
|[[:human genes:s:smtn|SMTN]]|0.409|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.408|
|[[:human genes:t:tceb3c|TCEB3C]]|0.408|
|[[:human genes:c:cbwd3|CBWD3]]|0.407|
|[[:human genes:t:tfip11|TFIP11]]|0.407|
|[[:human genes:c:ctage4|CTAGE4]]|0.407|
|[[:human genes:p:pcf11|PCF11]]|0.407|
|[[:human genes:c:ccdc116|CCDC116]]|0.407|
|[[:human genes:v:vps28|VPS28]]|0.406|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.405|
|[[:human genes:p:paf1|PAF1]]|0.405|
|[[:human genes:m:mbtd1|MBTD1]]|0.405|
|[[:human genes:t:tspy8|TSPY8]]|0.403|
|[[:human genes:p:psmb3|PSMB3]]|0.403|
|[[:human genes:c:cbwd5|CBWD5]]|0.402|
|[[:human genes:s:scaf1|SCAF1]]|0.402|
|[[:human genes:a:arcn1|ARCN1]]|0.401|
|[[:human genes:s:smg1|SMG1]]|0.4|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 712/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|23/26|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CDT1 Expression in NALM6 Cells: 6.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>