CEBPG [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= CEBPG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEBPG
  * **<color #00a2e8>Official Name</color>**: CCAAT enhancer binding protein gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1054|1054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53567|P53567]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEBPG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEBPG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138972|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II proximal promoter sequence-specific DNA binding, bending|
|enucleate erythrocyte differentiation|
|positive regulation of interferon-gamma biosynthetic process|
|regulation of interferon-gamma biosynthetic process|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|leukocyte mediated cytotoxicity|
|positive regulation of DNA binding|
|positive regulation of interferon-gamma production|
|positive regulation of DNA repair|
|positive regulation of cytokine biosynthetic process|
|erythrocyte differentiation|
|cell killing|
|erythrocyte homeostasis|
|positive regulation of response to DNA damage stimulus|
|regulation of interferon-gamma production|
|regulation of cytokine biosynthetic process|
|myeloid cell homeostasis|
|B cell differentiation|
|regulation of DNA repair|
|liver development|
|regulation of DNA binding|
|hepaticobiliary system development|
|B cell activation|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of binding|
|positive regulation of DNA metabolic process|
|homeostasis of number of cells|
|regulation of response to DNA damage stimulus|
|myeloid cell differentiation|
|lymphocyte differentiation|
|positive regulation of DNA-binding transcription factor activity|
|lymphocyte mediated immunity|
|leukocyte differentiation|
|transcription factor binding|
|regulation of DNA metabolic process|
|regulation of binding|
|lymphocyte activation|
|gland development|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|protein heterodimerization activity|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|regulation of cytokine production|
|mRNA metabolic process|
|regulation of cellular response to stress|
|leukocyte mediated immunity|
|innate immune response|
|protein homodimerization activity|
|leukocyte activation|
|defense response to other organism|
|cell activation|
|immune effector process|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|DNA binding|
|regulation of response to stress|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.08|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.98|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.88|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.81|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.7|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.7|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.73|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.76|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.8|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.8|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.93|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.1|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.18|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.64|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.85|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|3.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:eif2ak4|EIF2AK4]]|0.45|
|[[:human genes:i:ikzf2|IKZF2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16764
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEBPG Expression in NALM6 Cells: 6.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>