CEBPG

Entrez Summary: N/A
UniProt Summary: Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. {ECO:0000250|UniProtKB:P26801, ECO:0000250|UniProtKB:P53568, ECO:0000269|PubMed:7665092}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UMK57 1μM R01 exp59	-2.08
Nocodazole 0.2μM R00 exp24	-1.98
Rotenone 2μM R00 exp33	-1.88
Vinblastine 0.002μM R01 exp60	-1.81
SGC2043 10μM R03 exp152	1.7
Wortmannin 5μM R00 exp38	1.7
GSK626616 14μM R08 exp485	1.73
Pyridostatin 4μM R05 exp240	1.76
Cisplatin 0.35μM R06 exp273	1.8
Temozolomide 200μM R04 exp189	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	1.93
Thimerosal 0.85μM R08 exp529	2.1
Caffeine 2600μM R08 exp463	2.18
TRAIL 5ng/ml R00 exp35	2.64
MK-1775 0.32μM R02 exp75	2.85
Erlotinib 10μM R05 exp216	3.5

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
EIF2AK4	0.45
IKZF2	0.404

RNA polymerase II proximal promoter sequence-specific DNA binding, bending
enucleate erythrocyte differentiation
positive regulation of interferon-gamma biosynthetic process
regulation of interferon-gamma biosynthetic process
natural killer cell mediated cytotoxicity
natural killer cell mediated immunity
leukocyte mediated cytotoxicity
positive regulation of DNA binding
positive regulation of interferon-gamma production
positive regulation of DNA repair
positive regulation of cytokine biosynthetic process
erythrocyte differentiation
cell killing
erythrocyte homeostasis
positive regulation of response to DNA damage stimulus
regulation of interferon-gamma production
regulation of cytokine biosynthetic process
myeloid cell homeostasis
B cell differentiation
regulation of DNA repair
liver development
regulation of DNA binding
hepaticobiliary system development
B cell activation
negative regulation of DNA-binding transcription factor activity
positive regulation of binding
positive regulation of DNA metabolic process
homeostasis of number of cells
regulation of response to DNA damage stimulus
myeloid cell differentiation
lymphocyte differentiation
positive regulation of DNA-binding transcription factor activity
lymphocyte mediated immunity
leukocyte differentiation
transcription factor binding
regulation of DNA metabolic process
regulation of binding
lymphocyte activation
gland development
sequence-specific DNA binding