CELF4

Gene Information

Official Symbol: CELF4
Official Name: CUGBP Elav-like family member 4
Aliases and Previous Symbols: N/A
Entrez ID: 56853
UniProt: Q9BZC1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314, ECO:0000269|PubMed:12649496, ECO:0000269|PubMed:14973222, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:15894795}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5659
Expression level (log2 read counts): 2.05

Expression Distribution

BRE binding
regulation of retina development in camera-type eye
negative regulation of excitatory postsynaptic potential
pre-mRNA binding
translation repressor activity, mRNA regulatory element binding
alternative mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
positive regulation of mRNA splicing, via spliceosome
negative regulation of RNA splicing
negative regulation of nervous system process
negative regulation of mRNA processing
mRNA splice site selection
positive regulation of mRNA processing
positive regulation of RNA splicing
modulation of excitatory postsynaptic potential
spliceosomal complex assembly
negative regulation of synaptic transmission
regulation of alternative mRNA splicing, via spliceosome
positive regulation of mRNA metabolic process
negative regulation of mRNA metabolic process
regulation of mRNA splicing, via spliceosome
negative regulation of translation
regulation of RNA splicing
regulation of nervous system process
regulation of mRNA processing
negative regulation of cellular amide metabolic process
ribonucleoprotein complex
mRNA binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
germ cell development
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
regulation of mRNA metabolic process
regulation of translation
cellular process involved in reproduction in multicellular organism
in utero embryonic development
RNA splicing
regulation of cellular amide metabolic process