CEP192 [The Human Chemical-Genetic Interaction Map Project]

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======= CEP192 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CEP192
  * **<color #00a2e8>Official Name</color>**: centrosomal protein 192
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55125|55125]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEP8|Q8TEP8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CEP192&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CEP192|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. {ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|centrosome-templated microtubule nucleation|
|microtubule nucleation by microtubule organizing center|
|microtubule nucleation|
|protein localization to centrosome|
|pericentriolar material|
|protein localization to microtubule organizing center|
|centrosome duplication|
|microtubule polymerization|
|protein localization to microtubule cytoskeleton|
|mitotic spindle assembly|
|protein localization to cytoskeleton|
|phosphatase binding|
|microtubule polymerization or depolymerization|
|mitotic spindle organization|
|centrosome cycle|
|protein polymerization|
|microtubule organizing center organization|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|microtubule cytoskeleton organization involved in mitosis|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|centriole|
|mitotic nuclear division|
|spindle organization|
|organelle localization by membrane tethering|
|regulation of phosphatase activity|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of dephosphorylation|
|regulation of cell cycle G2/M phase transition|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|organelle fission|
|cilium assembly|
|cilium organization|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|organelle localization|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|response to bacterium|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.42|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.15|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.87|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.79|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.79|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.8|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|1.83|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.86|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.86|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.87|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.88|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.89|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.92|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|2.04|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.07|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.15|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.33|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.35|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.49|
|[[:results:exp453|B02 10μM R08 exp453]]|2.68|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ik|IK]]|0.544|
|[[:human genes:p:psmb4|PSMB4]]|0.539|
|[[:human genes:v:vasn|VASN]]|0.525|
|[[:human genes:c:cbwd5|CBWD5]]|0.522|
|[[:human genes:c:cbwd6|CBWD6]]|0.522|
|[[:human genes:c:cbwd3|CBWD3]]|0.521|
|[[:human genes:t:tfip11|TFIP11]]|0.516|
|[[:human genes:t:twistnb|TWISTNB]]|0.508|
|[[:human genes:s:supt5h|SUPT5H]]|0.507|
|[[:human genes:r:rrp15|RRP15]]|0.493|
|[[:human genes:c:cdc6|CDC6]]|0.493|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.49|
|[[:human genes:r:rps9|RPS9]]|0.49|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.488|
|[[:human genes:d:dtl|DTL]]|0.485|
|[[:human genes:c:copg1|COPG1]]|0.484|
|[[:human genes:p:paf1|PAF1]]|0.48|
|[[:human genes:c:chd4|CHD4]]|0.48|
|[[:human genes:t:tceb3c|TCEB3C]]|0.479|
|[[:human genes:t:ticrr|TICRR]]|0.478|
|[[:human genes:p:psma6|PSMA6]]|0.477|
|[[:human genes:r:rpl34|RPL34]]|0.472|
|[[:human genes:c:cgb2|CGB2]]|0.47|
|[[:human genes:u:utp3|UTP3]]|0.469|
|[[:human genes:v:vps28|VPS28]]|0.469|
|[[:human genes:a:aamp|AAMP]]|0.468|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.466|
|[[:human genes:m:mt1e|MT1E]]|0.465|
|[[:human genes:e:eif4a3|EIF4A3]]|0.464|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.463|
|[[:human genes:s:sf3a2|SF3A2]]|0.461|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.459|
|[[:human genes:c:c14orf93|C14orf93]]|0.458|
|[[:human genes:o:orc1|ORC1]]|0.458|
|[[:human genes:n:npipb5|NPIPB5]]|0.457|
|[[:human genes:r:ranbp2|RANBP2]]|0.457|
|[[:human genes:t:tspy8|TSPY8]]|0.457|
|[[:human genes:g:golga8j|GOLGA8J]]|0.454|
|[[:human genes:s:supt6h|SUPT6H]]|0.454|
|[[:human genes:r:rpl35|RPL35]]|0.454|
|[[:human genes:o:or10g3|OR10G3]]|0.453|
|[[:human genes:c:ckap5|CKAP5]]|0.451|
|[[:human genes:b:bage|BAGE]]|0.45|
|[[:human genes:r:rbm39|RBM39]]|0.45|
|[[:human genes:b:bage5|BAGE5]]|0.45|
|[[:human genes:b:bage2|BAGE2]]|0.45|
|[[:human genes:b:bage3|BAGE3]]|0.45|
|[[:human genes:s:sf3a1|SF3A1]]|0.45|
|[[:human genes:p:psmc1|PSMC1]]|0.45|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.449|
|[[:human genes:b:bage4|BAGE4]]|0.449|
|[[:human genes:n:nol10|NOL10]]|0.449|
|[[:human genes:p:psmb2|PSMB2]]|0.448|
|[[:human genes:r:rpl14|RPL14]]|0.448|
|[[:human genes:g:golga8o|GOLGA8O]]|0.447|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.446|
|[[:human genes:c:cdc73|CDC73]]|0.446|
|[[:human genes:c:cln6|CLN6]]|0.445|
|[[:human genes:r:rnf113a|RNF113A]]|0.444|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.443|
|[[:human genes:n:nupl1|NUPL1]]|0.443|
|[[:human genes:n:narfl|NARFL]]|0.442|
|[[:human genes:i:ints1|INTS1]]|0.441|
|[[:human genes:p:parp3|PARP3]]|0.441|
|[[:human genes:z:znf830|ZNF830]]|0.441|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.44|
|[[:human genes:s:sf3a3|SF3A3]]|0.44|
|[[:human genes:p:plekha4|PLEKHA4]]|0.44|
|[[:human genes:r:rps2|RPS2]]|0.439|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.438|
|[[:human genes:e:exosc9|EXOSC9]]|0.438|
|[[:human genes:c:col2a1|COL2A1]]|0.438|
|[[:human genes:r:rps12|RPS12]]|0.438|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.438|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.437|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.437|
|[[:human genes:t:tyms|TYMS]]|0.434|
|[[:human genes:e:exosc3|EXOSC3]]|0.432|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.432|
|[[:human genes:c:cdca3|CDCA3]]|0.432|
|[[:human genes:r:rpl6|RPL6]]|0.431|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.43|
|[[:human genes:r:rpl26|RPL26]]|0.43|
|[[:human genes:c:ctage4|CTAGE4]]|0.428|
|[[:human genes:e:egr2|EGR2]]|0.428|
|[[:human genes:s:slc4a1|SLC4A1]]|0.427|
|[[:human genes:c:cdca5|CDCA5]]|0.427|
|[[:human genes:t:terf1|TERF1]]|0.427|
|[[:human genes:r:rrp7a|RRP7A]]|0.426|
|[[:human genes:d:dhx38|DHX38]]|0.426|
|[[:human genes:a:aqr|AQR]]|0.425|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.424|
|[[:human genes:f:fam160a1|FAM160A1]]|0.424|
|[[:human genes:c:ccna2|CCNA2]]|0.424|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.424|
|[[:human genes:p:psma7|PSMA7]]|0.423|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.423|
|[[:human genes:t:tsg101|TSG101]]|0.423|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.422|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.422|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.421|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.421|
|[[:human genes:c:cdc45|CDC45]]|0.42|
|[[:human genes:b:bysl|BYSL]]|0.419|
|[[:human genes:p:psmb3|PSMB3]]|0.419|
|[[:human genes:d:dock6|DOCK6]]|0.419|
|[[:human genes:s:slc6a17|SLC6A17]]|0.418|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.418|
|[[:human genes:c:copb1|COPB1]]|0.417|
|[[:human genes:t:taf15|TAF15]]|0.417|
|[[:human genes:o:ogfr|OGFR]]|0.417|
|[[:human genes:p:pan3|PAN3]]|0.417|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.416|
|[[:human genes:n:nipbl|NIPBL]]|0.416|
|[[:human genes:h:hap1|HAP1]]|0.415|
|[[:human genes:m:myb|MYB]]|0.415|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.415|
|[[:human genes:a:aatf|AATF]]|0.414|
|[[:human genes:c:cactin|CACTIN]]|0.413|
|[[:human genes:n:nbpf10|NBPF10]]|0.412|
|[[:human genes:l:lrr1|LRR1]]|0.412|
|[[:human genes:c:chmp4b|CHMP4B]]|0.411|
|[[:human genes:o:osbp|OSBP]]|0.411|
|[[:human genes:e:exosc6|EXOSC6]]|0.41|
|[[:human genes:o:orc6|ORC6]]|0.41|
|[[:human genes:s:snip1|SNIP1]]|0.409|
|[[:human genes:f:fam231c|FAM231C]]|0.409|
|[[:human genes:r:rnpc3|RNPC3]]|0.409|
|[[:human genes:p:polr2a|POLR2A]]|0.409|
|[[:human genes:z:znf655|ZNF655]]|0.409|
|[[:human genes:p:polr1a|POLR1A]]|0.408|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.408|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:f:fam231a|FAM231A]]|0.408|
|[[:human genes:a:akt1s1|AKT1S1]]|0.408|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.407|
|[[:human genes:c:ctr9|CTR9]]|0.407|
|[[:human genes:t:tuba8|TUBA8]]|0.406|
|[[:human genes:d:ddtl|DDTL]]|0.406|
|[[:human genes:c:ccdc116|CCDC116]]|0.406|
|[[:human genes:c:cnot3|CNOT3]]|0.405|
|[[:human genes:w:wdr75|WDR75]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.404|
|[[:human genes:p:psmc6|PSMC6]]|0.403|
|[[:human genes:h:hinfp|HINFP]]|0.402|
|[[:human genes:t:tinf2|TINF2]]|0.402|
|[[:human genes:p:pcf11|PCF11]]|0.402|
|[[:human genes:r:rpl30|RPL30]]|0.402|
|[[:human genes:c:ccdc94|CCDC94]]|0.401|
|[[:human genes:d:disp2|DISP2]]|0.401|
|[[:human genes:t:timeless|TIMELESS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 197/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|4/28|
|bone|5/26|
|breast|8/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|5/21|
|liver|6/20|
|lung|19/75|
|lymphocyte|5/16|
|ovary|5/26|
|pancreas|6/24|
|peripheral nervous system|9/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|8/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 258
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CEP192 Expression in NALM6 Cells: 7.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>