CEP192

Gene Information

Official Symbol: CEP192
Official Name: centrosomal protein 192
Aliases and Previous Symbols: N/A
Entrez ID: 55125
UniProt: Q8TEP8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. {ECO:0000269|PubMed:17980596, ECO:0000269|PubMed:18207742}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 0.3μM R05 exp199	-2.42
Oligomycin-A 20μM R00 exp26	-2.15
Bleomycin 5μM R08 exp459	-1.87
UM131593 0.2μM R03 exp106	-1.86
Ethanol 0.01 R05 exp234	1.79
Nifuroxazide 1μM R01 exp51	1.79
Bisphenol F 50μM R08 exp457	1.8
LB-100 4.1μM R02 exp72	1.83
Isonicotinamide 500μM R03 exp129	1.86
proTAME 5μM R04 exp187	1.86
Cycloheximide 0.02μM R00 exp14	1.87
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.88
THZ531 0.11 to 0.125μM on day4 R07 exp410	1.89
Cyclosporin-A 3μM R07 exp348	1.92
BAY-598 4μM R05 exp220	2.04
RS-1 10μM R08 exp519	2.07
Calcipotriol 5μM R08 exp464	2.15
All-trans-Retinoic-Acid 8μM R07 exp333	2.33
Citral 50μM R06 exp274	2.35
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.49
B02 10μM R08 exp453	2.68
Cadmium 60μM R08 exp462	2.78

Gene	Correlation
IK	0.544
PSMB4	0.539
VASN	0.525
CBWD5	0.522
CBWD6	0.522
CBWD3	0.521
TFIP11	0.516
TWISTNB	0.508
SUPT5H	0.507
RRP15	0.493
CDC6	0.493
GOLGA6L1	0.49
RPS9	0.49
TCEB3CL	0.488
DTL	0.485
COPG1	0.484
PAF1	0.48
CHD4	0.48
TCEB3C	0.479
TICRR	0.478
PSMA6	0.477
RPL34	0.472
CGB2	0.47
UTP3	0.469
VPS28	0.469
AAMP	0.468
TBC1D3H	0.466
MT1E	0.465
EIF4A3	0.464
TCEB3CL2	0.463
SF3A2	0.461
C1QTNF9B	0.459
C14orf93	0.458
ORC1	0.458
NPIPB5	0.457
RANBP2	0.457
TSPY8	0.457
GOLGA8J	0.454
SUPT6H	0.454
RPL35	0.454
OR10G3	0.453
CKAP5	0.451
BAGE	0.45
RBM39	0.45
BAGE5	0.45
BAGE2	0.45
BAGE3	0.45
SF3A1	0.45
PSMC1	0.45
GOLGA6L6	0.449
BAGE4	0.449
NOL10	0.449
PSMB2	0.448
RPL14	0.448
GOLGA8O	0.447
TBC1D3G	0.446
CDC73	0.446
CLN6	0.445
RNF113A	0.444
ATP6V1C1	0.443
NUPL1	0.443
NARFL	0.442
INTS1	0.441
PARP3	0.441
ZNF830	0.441
C2orf27B	0.44
SF3A3	0.44
PLEKHA4	0.44
RPS2	0.439
TBC1D3F	0.438
TP53TG3	0.438
EXOSC9	0.438
COL2A1	0.438
RPS12	0.438
TP53TG3B	0.438
TP53TG3D	0.437
TP53TG3C	0.437
TYMS	0.434
EXOSC3	0.432
ATP6V1A	0.432
CDCA3	0.432
RPL6	0.431
TBC1D3	0.43
RPL26	0.43
CTAGE4	0.428
EGR2	0.428
SLC4A1	0.427
CDCA5	0.427
TERF1	0.427
RRP7A	0.426
DHX38	0.426
AQR	0.425
RPS19BP1	0.424
FAM160A1	0.424
CCNA2	0.424
COX7A2L	0.424
PSMA7	0.423
ATP6V1B2	0.423
TSG101	0.423
TBC1D3E	0.422
TBC1D3I	0.422
TBC1D3L	0.421
TBC1D3K	0.421
CDC45	0.42
BYSL	0.419
PSMB3	0.419
DOCK6	0.419
SLC6A17	0.418
TBC1D3C	0.418
COPB1	0.417
TAF15	0.417
OGFR	0.417
PAN3	0.417
ATP6AP1	0.416
NIPBL	0.416
HAP1	0.415
MYB	0.415
PDE4DIP	0.415
AATF	0.414
CACTIN	0.413
NBPF10	0.412
LRR1	0.412
CHMP4B	0.411
OSBP	0.411
EXOSC6	0.41
ORC6	0.41
SNIP1	0.409
FAM231C	0.409
RNPC3	0.409
POLR2A	0.409
ZNF655	0.409
POLR1A	0.408
HIST2H3A	0.408
POLR2J3	0.408
FAM231A	0.408
AKT1S1	0.408
HIST2H3C	0.407
CTR9	0.407
TUBA8	0.406
DDTL	0.406
CCDC116	0.406
CNOT3	0.405
WDR75	0.404
RPS5	0.404
PSMC6	0.403
HINFP	0.402
TINF2	0.402
PCF11	0.402
RPL30	0.402
CCDC94	0.401
DISP2	0.401
TIMELESS	0.4

Global Fraction of Cell Lines Where Essential: 197/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	8/28
blood	4/28
bone	5/26
breast	8/33
central nervous system	16/56
cervix	0/4
colorectal	5/17
esophagus	2/13
fibroblast	0/1
gastric	2/16
kidney	5/21
liver	6/20
lung	19/75
lymphocyte	5/16
ovary	5/26
pancreas	6/24
peripheral nervous system	9/16
plasma cell	2/15
prostate	1/1
skin	6/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	8/22
urinary tract	8/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 258
Expression level (log2 read counts): 7.35

Expression Distribution

centrosome-templated microtubule nucleation
microtubule nucleation by microtubule organizing center
microtubule nucleation
protein localization to centrosome
pericentriolar material
protein localization to microtubule organizing center
centrosome duplication
microtubule polymerization
protein localization to microtubule cytoskeleton
mitotic spindle assembly
protein localization to cytoskeleton
phosphatase binding
microtubule polymerization or depolymerization
mitotic spindle organization
centrosome cycle
protein polymerization
microtubule organizing center organization
ciliary basal body-plasma membrane docking
spindle assembly
microtubule cytoskeleton organization involved in mitosis
negative regulation of phosphatase activity
negative regulation of dephosphorylation
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
centriole
mitotic nuclear division
spindle organization
organelle localization by membrane tethering
regulation of phosphatase activity
membrane docking
regulation of G2/M transition of mitotic cell cycle
regulation of dephosphorylation
regulation of cell cycle G2/M phase transition
mitotic cell cycle phase transition
cell cycle phase transition
nuclear division
organelle fission
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition