CEP250

Entrez Summary: This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
UniProt Summary: Probably plays an important role in centrosome cohesion during interphase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of centriole-centriole cohesion
positive regulation of protein localization to centrosome
regulation of protein localization to centrosome
centriole-centriole cohesion
detection of light stimulus involved in sensory perception
detection of light stimulus involved in visual perception
non-motile cilium assembly
detection of visible light
photoreceptor inner segment
regulation of centrosome cycle
photoreceptor outer segment
detection of light stimulus
centrosome cycle
microtubule organizing center organization
ciliary basal body-plasma membrane docking
detection of external stimulus
detection of abiotic stimulus
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
ciliary basal body
centriole
microtubule organizing center
organelle localization by membrane tethering
membrane docking
protein C-terminus binding
regulation of microtubule cytoskeleton organization
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
visual perception
regulation of microtubule-based process
sensory perception of light stimulus
protein domain specific binding
mitotic cell cycle phase transition
cell cycle phase transition
response to light stimulus
positive regulation of cellular protein localization
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
response to radiation