CEP72

Entrez Summary: N/A
UniProt Summary: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). {ECO:0000269|PubMed:19536135, ECO:0000269|PubMed:26297806}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

gamma-tubulin complex localization
regulation of protein localization to centrosome
centriole replication
cellular protein-containing complex localization
centriole assembly
centrosome duplication
centriolar satellite
centrosome cycle
microtubule organizing center organization
ciliary basal body-plasma membrane docking
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
spindle organization
organelle localization by membrane tethering
membrane docking
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
protein-containing complex localization
mitotic cell cycle phase transition
cell cycle phase transition
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
microtubule cytoskeleton organization
centrosome
regulation of cellular protein localization
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle
regulation of cell cycle process
organelle assembly
regulation of cellular localization
cell cycle process
regulation of protein localization
identical protein binding