CER1 [The Human Chemical-Genetic Interaction Map Project]

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======= CER1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CER1
  * **<color #00a2e8>Official Name</color>**: cerberus 1, DAN family BMP antagonist
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9350|9350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95813|O95813]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CER1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CER1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAN|
|Cys knot|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|negative regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|growth plate cartilage chondrocyte proliferation|
|negative regulation of nodal signaling pathway|
|sequestering of BMP in extracellular matrix|
|regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|determination of dorsal identity|
|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|determination of dorsal/ventral asymmetry|
|morphogen activity|
|maintenance of protein location in extracellular region|
|regulation of nodal signaling pathway|
|negative regulation of mesoderm development|
|sequestering of extracellular ligand from receptor|
|negative regulation of activin receptor signaling pathway|
|extracellular regulation of signal transduction|
|BMP binding|
|extracellular negative regulation of signal transduction|
|cell migration involved in gastrulation|
|regulation of mesoderm development|
|signal transduction involved in regulation of gene expression|
|regulation of activin receptor signaling pathway|
|growth plate cartilage development|
|endochondral bone growth|
|bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|bone mineralization|
|negative regulation of BMP signaling pathway|
|anterior/posterior axis specification|
|determination of heart left/right asymmetry|
|endochondral bone morphogenesis|
|dorsal/ventral pattern formation|
|ureteric bud development|
|axis specification|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|mesonephros development|
|biomineral tissue development|
|biomineralization|
|organ growth|
|cellular response to BMP stimulus|
|response to BMP|
|maintenance of protein location|
|bone morphogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|kidney epithelium development|
|negative regulation of cellular response to growth factor stimulus|
|gastrulation|
|maintenance of location|
|protein localization to extracellular region|
|ameboidal-type cell migration|
|cartilage development|
|cytokine activity|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|negative regulation of Wnt signaling pathway|
|anterior/posterior pattern specification|
|connective tissue development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|ossification|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|renal system development|
|urogenital system development|
|regionalization|
|regulation of Wnt signaling pathway|
|developmental growth|
|growth|
|pattern specification process|
|skeletal system development|
|cellular response to growth factor stimulus|
|heart development|
|response to growth factor|
|cell population proliferation|
|embryonic morphogenesis|
|negative regulation of cell population proliferation|
|enzyme linked receptor protein signaling pathway|
|tube development|
|circulatory system development|
|protein homodimerization activity|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13438
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CER1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>