CER1
Gene Information
- Official Symbol: CER1
- Official Name: cerberus 1, DAN family BMP antagonist
- Aliases and Previous Symbols: N/A
- Entrez ID: 9350
- UniProt: O95813
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| DAN |
| Cys knot |
GO Terms
| negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| negative regulation of nodal signaling pathway involved in determination of left/right asymmetry |
| growth plate cartilage chondrocyte proliferation |
| negative regulation of nodal signaling pathway |
| sequestering of BMP in extracellular matrix |
| regulation of nodal signaling pathway involved in determination of left/right asymmetry |
| determination of dorsal identity |
| regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| determination of dorsal/ventral asymmetry |
| morphogen activity |
| maintenance of protein location in extracellular region |
| regulation of nodal signaling pathway |
| negative regulation of mesoderm development |
| sequestering of extracellular ligand from receptor |
| negative regulation of activin receptor signaling pathway |
| extracellular regulation of signal transduction |
| BMP binding |
| extracellular negative regulation of signal transduction |
| cell migration involved in gastrulation |
| regulation of mesoderm development |
| signal transduction involved in regulation of gene expression |
| regulation of activin receptor signaling pathway |
| growth plate cartilage development |
| endochondral bone growth |
| bone growth |
| cartilage development involved in endochondral bone morphogenesis |
| bone mineralization |
| negative regulation of BMP signaling pathway |
| anterior/posterior axis specification |
| determination of heart left/right asymmetry |
| endochondral bone morphogenesis |
| dorsal/ventral pattern formation |
| ureteric bud development |
| axis specification |
| mesonephric epithelium development |
| mesonephric tubule development |
| regulation of BMP signaling pathway |
| BMP signaling pathway |
| mesonephros development |
| biomineral tissue development |
| biomineralization |
| organ growth |
| cellular response to BMP stimulus |
| response to BMP |
| maintenance of protein location |
| bone morphogenesis |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| specification of symmetry |
| kidney epithelium development |
| negative regulation of cellular response to growth factor stimulus |
| gastrulation |
| maintenance of location |
| protein localization to extracellular region |
| ameboidal-type cell migration |
| cartilage development |
| cytokine activity |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| negative regulation of Wnt signaling pathway |
| anterior/posterior pattern specification |
| connective tissue development |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| ossification |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| renal system development |
| urogenital system development |
| regionalization |
| regulation of Wnt signaling pathway |
| developmental growth |
| growth |
| pattern specification process |
| skeletal system development |
| cellular response to growth factor stimulus |
| heart development |
| response to growth factor |
| cell population proliferation |
| embryonic morphogenesis |
| negative regulation of cell population proliferation |
| enzyme linked receptor protein signaling pathway |
| tube development |
| circulatory system development |
| protein homodimerization activity |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| embryo development |
| cell motility |
| localization of cell |
| epithelium development |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| locomotion |
| negative regulation of cell communication |
| negative regulation of signaling |
| response to endogenous stimulus |
| movement of cell or subcellular component |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| tissue development |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13438
- Expression level (log2 read counts): -7.68
Expression Distribution
CER1 Expression in NALM6 Cells: -7.68
