CERS2 [The Human Chemical-Genetic Interaction Map Project]

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======= CERS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CERS2
  * **<color #00a2e8>Official Name</color>**: ceramide synthase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29956|29956]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96G23|Q96G23]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CERS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CERS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRAM LAG1 CLN8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Schwann cell migration|
|negative regulation of Schwann cell proliferation involved in axon regeneration|
|regulation of Schwann cell proliferation involved in axon regeneration|
|regulation of Schwann cell migration|
|negative regulation of glial cell migration|
|regulation of Schwann cell proliferation|
|negative regulation of Schwann cell proliferation|
|sphingosine N-acyltransferase activity|
|negative regulation of axon regeneration|
|negative regulation of glial cell proliferation|
|regulation of glial cell migration|
|negative regulation of neuron projection regeneration|
|regulation of axon regeneration|
|regulation of neuron projection regeneration|
|regulation of glial cell proliferation|
|negative regulation of gliogenesis|
|ceramide biosynthetic process|
|ceramide metabolic process|
|negative regulation of response to wounding|
|sphingolipid biosynthetic process|
|regulation of gliogenesis|
|membrane lipid biosynthetic process|
|negative regulation of neuron projection development|
|sphingolipid metabolic process|
|regulation of response to wounding|
|negative regulation of cell projection organization|
|membrane lipid metabolic process|
|negative regulation of neuron differentiation|
|nuclear membrane|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|regulation of neuron projection development|
|amide biosynthetic process|
|lipid biosynthetic process|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|cellular amide metabolic process|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|regulation of locomotion|
|regulation of cellular component movement|
|endoplasmic reticulum|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|DNA binding|
|regulation of response to stress|
|generation of neurons|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.4|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.26|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.02|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.99|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.96|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.85|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.71|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.05|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.71|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|2/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3136
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CERS2 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>