CERS2
Gene Information
- Official Symbol: CERS2
- Official Name: ceramide synthase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 29956
- UniProt: Q96G23
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
Pfam Domains GO Terms
Pfam Domains
| TRAM LAG1 CLN8 |
GO Terms
| negative regulation of Schwann cell migration |
| negative regulation of Schwann cell proliferation involved in axon regeneration |
| regulation of Schwann cell proliferation involved in axon regeneration |
| regulation of Schwann cell migration |
| negative regulation of glial cell migration |
| regulation of Schwann cell proliferation |
| negative regulation of Schwann cell proliferation |
| sphingosine N-acyltransferase activity |
| negative regulation of axon regeneration |
| negative regulation of glial cell proliferation |
| regulation of glial cell migration |
| negative regulation of neuron projection regeneration |
| regulation of axon regeneration |
| regulation of neuron projection regeneration |
| regulation of glial cell proliferation |
| negative regulation of gliogenesis |
| ceramide biosynthetic process |
| ceramide metabolic process |
| negative regulation of response to wounding |
| sphingolipid biosynthetic process |
| regulation of gliogenesis |
| membrane lipid biosynthetic process |
| negative regulation of neuron projection development |
| sphingolipid metabolic process |
| regulation of response to wounding |
| negative regulation of cell projection organization |
| membrane lipid metabolic process |
| negative regulation of neuron differentiation |
| nuclear membrane |
| negative regulation of cell migration |
| negative regulation of cell motility |
| negative regulation of neurogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| negative regulation of cell development |
| negative regulation of response to external stimulus |
| regulation of neuron projection development |
| amide biosynthetic process |
| lipid biosynthetic process |
| regulation of neuron differentiation |
| negative regulation of cell population proliferation |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| regulation of cellular response to stress |
| cellular amide metabolic process |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| endoplasmic reticulum membrane |
| negative regulation of developmental process |
| cellular lipid metabolic process |
| regulation of locomotion |
| regulation of cellular component movement |
| endoplasmic reticulum |
| regulation of response to external stimulus |
| negative regulation of multicellular organismal process |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
| DNA binding |
| regulation of response to stress |
| generation of neurons |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| regulation of cell differentiation |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 4/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3136
- Expression level (log2 read counts): 6.8
Expression Distribution
CERS2 Expression in NALM6 Cells: 6.8
