CES1

Entrez Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

COesterase
Abhydrolase 3

cholesterol ester hydrolysis involved in cholesterol transport
vesicle-mediated cholesterol transport
methylumbelliferyl-acetate deacetylase activity
methyl indole-3-acetate esterase activity
sterol esterase activity
medium-chain fatty acid metabolic process
regulation of angiotensin levels in blood
angiotensin maturation
regulation of systemic arterial blood pressure by circulatory renin-angiotensin
intracellular cholesterol transport
intracellular sterol transport
triglyceride lipase activity
regulation of systemic arterial blood pressure by renin-angiotensin
carboxylic ester hydrolase activity
peptide hormone processing
intracellular lipid transport
regulation of systemic arterial blood pressure by hormone
cholesterol biosynthetic process
secondary alcohol biosynthetic process
regulation of systemic arterial blood pressure mediated by a chemical signal
sterol biosynthetic process
endocrine process
cholesterol transport
sterol transport
regulation of systemic arterial blood pressure
alcohol biosynthetic process
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
xenobiotic metabolic process
sterol metabolic process
organic hydroxy compound transport
cytosolic transport
protein processing
regulation of blood pressure
organic hydroxy compound biosynthetic process
cellular response to xenobiotic stimulus
hormone metabolic process
protein maturation
steroid metabolic process