CES3

Entrez Summary: N/A
UniProt Summary: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
5-Fluorouracil 2μM R00 exp1	1.78
Oligomycin-A 20μM R00 exp26	1.92

COesterase
Abhydrolase 3

methyl indole-3-acetate esterase activity
sterol esterase activity
triglyceride lipase activity
low-density lipoprotein particle clearance
carboxylic ester hydrolase activity
plasma lipoprotein particle clearance
regulation of plasma lipoprotein particle levels
xenobiotic metabolic process
cellular response to xenobiotic stimulus
lipid catabolic process
response to xenobiotic stimulus
endoplasmic reticulum lumen
lipid metabolic process
extracellular space
organic substance catabolic process