CFL1 [The Human Chemical-Genetic Interaction Map Project]

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======= CFL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CFL1
  * **<color #00a2e8>Official Name</color>**: cofilin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1072|1072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23528|P23528]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CFL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CFL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601442|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cofilin ADF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament fragmentation|
|neural fold formation|
|actin filament depolymerization|
|positive regulation of actin filament depolymerization|
|positive regulation by host of viral process|
|morphogenesis of an epithelial fold|
|positive regulation of protein depolymerization|
|lamellipodium membrane|
|modulation by host of viral process|
|protein depolymerization|
|positive regulation of protein complex disassembly|
|regulation of dendritic spine morphogenesis|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|actin polymerization or depolymerization|
|regulation of actin filament depolymerization|
|cortical actin cytoskeleton|
|neural crest cell migration|
|mitotic cytokinesis|
|modification by host of symbiont morphology or physiology|
|regulation of dendritic spine development|
|interaction with symbiont|
|Rho protein signal transduction|
|neural crest cell development|
|mesenchymal cell development|
|regulation of protein depolymerization|
|stem cell development|
|neural crest cell differentiation|
|regulation of dendrite morphogenesis|
|ruffle membrane|
|cytoskeleton-dependent cytokinesis|
|regulation of postsynapse organization|
|primary neural tube formation|
|cytokinesis|
|neural tube formation|
|positive regulation of viral process|
|nuclear matrix|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|regulation of protein complex disassembly|
|response to amino acid|
|establishment of cell polarity|
|embryonic epithelial tube formation|
|epithelial tube formation|
|cellular protein complex disassembly|
|vesicle|
|morphogenesis of embryonic epithelium|
|tube formation|
|regulation of dendrite development|
|modification of morphology or physiology of other organism|
|mesenchymal cell differentiation|
|stem cell differentiation|
|neural tube development|
|cell-cell junction|
|ameboidal-type cell migration|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|regulation of viral process|
|regulation of synapse organization|
|regulation of symbiosis, encompassing mutualism through parasitism|
|positive regulation of cytoskeleton organization|
|mesenchyme development|
|regulation of synapse structure or activity|
|actin filament organization|
|protein-containing complex disassembly|
|Ras protein signal transduction|
|regulation of actin filament organization|
|response to virus|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|small GTPase mediated signal transduction|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|cellular component disassembly|
|focal adhesion|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|regulation of cell morphogenesis|
|cell division|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|cytokine-mediated signaling pathway|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of multi-organism process|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|tube development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|protein phosphorylation|
|embryo development|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|cell cycle|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|extracellular space|
|neurogenesis|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.21|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.04|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-2.04|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.87|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.83|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.77|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.76|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.7|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 146/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|10/28|
|bone|3/26|
|breast|5/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|5/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|11/75|
|lymphocyte|12/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 131
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CFL1 Expression in NALM6 Cells: 9.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>