CFL1

Entrez Summary: N/A
UniProt Summary: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity). {ECO:0000250|UniProtKB:P18760, ECO:0000269|PubMed:11812157, ECO:0000269|PubMed:15580268, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:23633677}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rapamycin 0.001μM R08 exp429	-2.21
Milciclib 2μM R08 exp502	-2.04
Phenformin 20μM R03 exp143	-2.04
Hydroxyurea 15μM R06 exp289	-2
Nicotine 3000μM R08 exp510	-1.87
HMS-I1 10μM R06 exp256	-1.83
Hydroxyurea 100μM R07 exp329	-1.77
D-Fructose 10000μM R06 exp279	-1.76
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.7
Dimethyl-Sulfoxide 1pc R03 exp120	1.83

Global Fraction of Cell Lines Where Essential: 146/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	10/28
bone	3/26
breast	5/33
central nervous system	2/56
cervix	0/4
colorectal	5/17
esophagus	7/13
fibroblast	0/1
gastric	1/16
kidney	1/21
liver	1/20
lung	11/75
lymphocyte	12/16
ovary	4/26
pancreas	4/24
peripheral nervous system	0/16
plasma cell	10/15
prostate	0/1
skin	1/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	8/22
urinary tract	3/29
uterus	0/5

Expression Distribution

actin filament fragmentation
neural fold formation
actin filament depolymerization
positive regulation of actin filament depolymerization
positive regulation by host of viral process
morphogenesis of an epithelial fold
positive regulation of protein depolymerization
lamellipodium membrane
modulation by host of viral process
protein depolymerization
positive regulation of protein complex disassembly
regulation of dendritic spine morphogenesis
interleukin-12-mediated signaling pathway
cellular response to interleukin-12
response to interleukin-12
actin polymerization or depolymerization
regulation of actin filament depolymerization
cortical actin cytoskeleton
neural crest cell migration
mitotic cytokinesis
modification by host of symbiont morphology or physiology
regulation of dendritic spine development
interaction with symbiont
Rho protein signal transduction
neural crest cell development
mesenchymal cell development
regulation of protein depolymerization
stem cell development
neural crest cell differentiation
regulation of dendrite morphogenesis
ruffle membrane
cytoskeleton-dependent cytokinesis
regulation of postsynapse organization
primary neural tube formation
cytokinesis
neural tube formation
positive regulation of viral process
nuclear matrix
modification of morphology or physiology of other organism involved in symbiotic interaction
regulation of protein complex disassembly