CHAT

Entrez Summary: This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010].
UniProt Summary: Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. {ECO:0000269|PubMed:17144655}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

choline O-acetyltransferase activity
acetate ester biosynthetic process
acetylcholine biosynthetic process
acetylcholine metabolic process
acetate ester metabolic process
neuromuscular synaptic transmission
phosphatidylcholine biosynthetic process
neurotransmitter biosynthetic process
hormone biosynthetic process
phosphatidylcholine metabolic process
neurotransmitter metabolic process
presynapse
neurotransmitter secretion
signal release from synapse
signal release
neurotransmitter transport
ammonium ion metabolic process
hormone metabolic process
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
neuron projection
regulation of neurotransmitter levels
phospholipid metabolic process
glycerolipid metabolic process
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling
synaptic signaling
drug metabolic process
regulation of hormone levels
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
secretion by cell
export from cell
cell-cell signaling
secretion