CHCHD10

Gene Information

Official Symbol: CHCHD10
Official Name: coiled-coil-helix-coiled-coil-helix domain containing 10
Aliases and Previous Symbols: N/A
Entrez ID: 400916
UniProt: Q8WYQ3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014].
UniProt Summary: May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. {ECO:0000269|PubMed:24934289}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10837
Expression level (log2 read counts): 4.48

Expression Distribution

nucleoid organization
mitochondrial nucleoid organization
positive regulation of mitochondrial transcription
positive regulation of cristae formation
regulation of cristae formation
positive regulation of cytochrome-c oxidase activity
regulation of mitochondrial transcription
positive regulation of electron transfer activity
regulation of cytochrome-c oxidase activity
regulation of electron transfer activity
MICOS complex
maintenance of synapse structure
stabilization of membrane potential
regulation of proton transport
regulation of mitochondrial gene expression
positive regulation of release of cytochrome c from mitochondria
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
cellular component maintenance
regulation of release of cytochrome c from mitochondria
positive regulation of oxidoreductase activity
regulation of mitochondrial membrane permeability
mitochondrial intermembrane space
regulation of membrane permeability
regulation of oxidoreductase activity
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
positive regulation of mitochondrion organization
oxidative phosphorylation
mitochondrial membrane organization
positive regulation of cation transmembrane transport
positive regulation of ion transmembrane transport
regulation of generation of precursor metabolites and energy
protein localization to nucleus
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of transmembrane transport
ATP metabolic process
mitochondrial transport
protein-containing complex disassembly