CHD4 [The Human Chemical-Genetic Interaction Map Project]

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======= CHD4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHD4
  * **<color #00a2e8>Official Name</color>**: chromodomain helicase DNA binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1108|1108]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14839|Q14839]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHD4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHD4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603277|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ResIII|
|Chromo|
|CHDNT|
|DUF1087|
|PHD|
|DUF1086|
|CHDCT2|
|HDA2-3|
|Helicase C|
|SNF2 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NuRD complex|
|RNA polymerase II repressing transcription factor binding|
|nucleosomal DNA binding|
|DNA helicase activity|
|ATP-dependent chromatin remodeling|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|DNA duplex unwinding|
|histone deacetylase binding|
|DNA geometric change|
|chromatin remodeling|
|regulation of signal transduction by p53 class mediator|
|nuclear chromatin|
|DNA conformation change|
|centrosome|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|protein-containing complex|
|chromatin organization|
|zinc ion binding|
|chromosome organization|
|DNA binding|
|ATP binding|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.17|
|[[:results:exp453|B02 10μM R08 exp453]]|1.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.71|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.74|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.77|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.78|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.78|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.89|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.91|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.92|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|2|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|2.03|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.632|
|[[:human genes:c:cbwd3|CBWD3]]|0.625|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.611|
|[[:human genes:m:mt1e|MT1E]]|0.607|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.6|
|[[:human genes:c:cbwd5|CBWD5]]|0.6|
|[[:human genes:c:cbwd6|CBWD6]]|0.599|
|[[:human genes:t:tceb3c|TCEB3C]]|0.595|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.593|
|[[:human genes:r:rps2|RPS2]]|0.591|
|[[:human genes:a:aamp|AAMP]]|0.589|
|[[:human genes:d:ddtl|DDTL]]|0.584|
|[[:human genes:k:kctd17|KCTD17]]|0.583|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.583|
|[[:human genes:t:tfip11|TFIP11]]|0.575|
|[[:human genes:c:ccna2|CCNA2]]|0.575|
|[[:human genes:o:orc1|ORC1]]|0.572|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.572|
|[[:human genes:s:slc4a1|SLC4A1]]|0.572|
|[[:human genes:p:polr2d|POLR2D]]|0.571|
|[[:human genes:p:pan3|PAN3]]|0.57|
|[[:human genes:s:supt5h|SUPT5H]]|0.569|
|[[:human genes:d:disp2|DISP2]]|0.568|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.568|
|[[:human genes:p:psma6|PSMA6]]|0.567|
|[[:human genes:c:copa|COPA]]|0.567|
|[[:human genes:t:ticrr|TICRR]]|0.566|
|[[:human genes:v:vasn|VASN]]|0.565|
|[[:human genes:p:psmd11|PSMD11]]|0.565|
|[[:human genes:p:pole|POLE]]|0.562|
|[[:human genes:c:c14orf93|C14orf93]]|0.561|
|[[:human genes:g:gid4|GID4]]|0.56|
|[[:human genes:t:tsg101|TSG101]]|0.553|
|[[:human genes:n:nupl1|NUPL1]]|0.552|
|[[:human genes:n:nol10|NOL10]]|0.549|
|[[:human genes:l:lrr1|LRR1]]|0.548|
|[[:human genes:m:myb|MYB]]|0.548|
|[[:human genes:o:orc6|ORC6]]|0.548|
|[[:human genes:e:exosc9|EXOSC9]]|0.547|
|[[:human genes:c:ctage4|CTAGE4]]|0.546|
|[[:human genes:z:zfand5|ZFAND5]]|0.546|
|[[:human genes:a:ankle2|ANKLE2]]|0.545|
|[[:human genes:p:polr2f|POLR2F]]|0.544|
|[[:human genes:s:slc6a17|SLC6A17]]|0.541|
|[[:human genes:r:rps12|RPS12]]|0.541|
|[[:human genes:z:znf830|ZNF830]]|0.539|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.538|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.537|
|[[:human genes:p:psmc6|PSMC6]]|0.537|
|[[:human genes:p:pan2|PAN2]]|0.537|
|[[:human genes:r:rpl35|RPL35]]|0.537|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.536|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.536|
|[[:human genes:s:sap30bp|SAP30BP]]|0.535|
|[[:human genes:p:paf1|PAF1]]|0.534|
|[[:human genes:n:npipb5|NPIPB5]]|0.533|
|[[:human genes:n:napa|NAPA]]|0.532|
|[[:human genes:c:copg1|COPG1]]|0.532|
|[[:human genes:c:cln6|CLN6]]|0.531|
|[[:human genes:a:aqr|AQR]]|0.531|
|[[:human genes:e:exosc5|EXOSC5]]|0.529|
|[[:human genes:p:pola1|POLA1]]|0.528|
|[[:human genes:n:narfl|NARFL]]|0.528|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.528|
|[[:human genes:c:cactin|CACTIN]]|0.526|
|[[:human genes:p:psmd3|PSMD3]]|0.526|
|[[:human genes:t:tuba8|TUBA8]]|0.525|
|[[:human genes:s:stil|STIL]]|0.525|
|[[:human genes:t:twistnb|TWISTNB]]|0.524|
|[[:human genes:c:copb1|COPB1]]|0.524|
|[[:human genes:m:myt1l|MYT1L]]|0.523|
|[[:human genes:a:aatf|AATF]]|0.522|
|[[:human genes:l:lad1|LAD1]]|0.52|
|[[:human genes:p:polr1a|POLR1A]]|0.52|
|[[:human genes:p:psmd2|PSMD2]]|0.519|
|[[:human genes:p:psma7|PSMA7]]|0.519|
|[[:human genes:r:rpl6|RPL6]]|0.519|
|[[:human genes:i:ik|IK]]|0.518|
|[[:human genes:o:osbp|OSBP]]|0.516|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.515|
|[[:human genes:n:nop16|NOP16]]|0.515|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.515|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.514|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.514|
|[[:human genes:d:dtl|DTL]]|0.513|
|[[:human genes:p:psmc1|PSMC1]]|0.513|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.513|
|[[:human genes:h:hivep3|HIVEP3]]|0.513|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.512|
|[[:human genes:p:pola2|POLA2]]|0.511|
|[[:human genes:p:psmc5|PSMC5]]|0.511|
|[[:human genes:b:brd2|BRD2]]|0.511|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.511|
|[[:human genes:r:rrp7a|RRP7A]]|0.511|
|[[:human genes:n:nup160|NUP160]]|0.51|
|[[:human genes:x:xylt2|XYLT2]]|0.51|
|[[:human genes:m:med14|MED14]]|0.509|
|[[:human genes:m:myo1h|MYO1H]]|0.508|
|[[:human genes:s:syt9|SYT9]]|0.508|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.506|
|[[:human genes:p:polr2j3|POLR2J3]]|0.506|
|[[:human genes:c:cdh24|CDH24]]|0.505|
|[[:human genes:s:ssh2|SSH2]]|0.505|
|[[:human genes:c:cope|COPE]]|0.504|
|[[:human genes:r:rnpc3|RNPC3]]|0.504|
|[[:human genes:r:rbm39|RBM39]]|0.503|
|[[:human genes:r:ranbp2|RANBP2]]|0.503|
|[[:human genes:p:psmb2|PSMB2]]|0.501|
|[[:human genes:s:sf3a1|SF3A1]]|0.501|
|[[:human genes:z:znf106|ZNF106]]|0.5|
|[[:human genes:u:upf1|UPF1]]|0.499|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.498|
|[[:human genes:a:arcn1|ARCN1]]|0.498|
|[[:human genes:p:psmc2|PSMC2]]|0.498|
|[[:human genes:c:col2a1|COL2A1]]|0.496|
|[[:human genes:a:ankle1|ANKLE1]]|0.496|
|[[:human genes:s:smg7|SMG7]]|0.496|
|[[:human genes:s:sf3a3|SF3A3]]|0.495|
|[[:human genes:e:exosc6|EXOSC6]]|0.495|
|[[:human genes:s:smg1|SMG1]]|0.494|
|[[:human genes:d:dhx38|DHX38]]|0.494|
|[[:human genes:t:timeless|TIMELESS]]|0.492|
|[[:human genes:p:prim1|PRIM1]]|0.491|
|[[:human genes:t:terf1|TERF1]]|0.49|
|[[:human genes:k:kpnb1|KPNB1]]|0.49|
|[[:human genes:h:hnrnpc|HNRNPC]]|0.49|
|[[:human genes:o:or10g3|OR10G3]]|0.49|
|[[:human genes:g:golga6a|GOLGA6A]]|0.489|
|[[:human genes:u:utp3|UTP3]]|0.489|
|[[:human genes:r:rrn3|RRN3]]|0.488|
|[[:human genes:d:ddt|DDT]]|0.488|
|[[:human genes:r:rps20|RPS20]]|0.488|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.488|
|[[:human genes:s:smtn|SMTN]]|0.488|
|[[:human genes:f:fbxw9|FBXW9]]|0.488|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.487|
|[[:human genes:m:mbtd1|MBTD1]]|0.486|
|[[:human genes:c:ccdc116|CCDC116]]|0.485|
|[[:human genes:u:uqcrh|UQCRH]]|0.485|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.483|
|[[:human genes:m:madcam1|MADCAM1]]|0.482|
|[[:human genes:p:psmd14|PSMD14]]|0.481|
|[[:human genes:s:supt6h|SUPT6H]]|0.48|
|[[:human genes:c:cdca3|CDCA3]]|0.48|
|[[:human genes:c:cep192|CEP192]]|0.48|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.479|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.478|
|[[:human genes:t:tspy8|TSPY8]]|0.478|
|[[:human genes:i:igfn1|IGFN1]]|0.478|
|[[:human genes:s:sec13|SEC13]]|0.477|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.477|
|[[:human genes:p:pwp2|PWP2]]|0.476|
|[[:human genes:r:rpl30|RPL30]]|0.475|
|[[:human genes:r:rad21|RAD21]]|0.475|
|[[:human genes:o:ogfr|OGFR]]|0.475|
|[[:human genes:r:rad51|RAD51]]|0.475|
|[[:human genes:r:rps19|RPS19]]|0.474|
|[[:human genes:n:nup205|NUP205]]|0.474|
|[[:human genes:e:exosc4|EXOSC4]]|0.474|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.474|
|[[:human genes:g:golga8o|GOLGA8O]]|0.473|
|[[:human genes:s:snrpa1|SNRPA1]]|0.473|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.472|
|[[:human genes:m:myo18a|MYO18A]]|0.471|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.471|
|[[:human genes:c:chaf1a|CHAF1A]]|0.47|
|[[:human genes:h:hap1|HAP1]]|0.469|
|[[:human genes:c:cdc6|CDC6]]|0.469|
|[[:human genes:d:dock6|DOCK6]]|0.469|
|[[:human genes:r:rfpl3|RFPL3]]|0.469|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.468|
|[[:human genes:n:nsf|NSF]]|0.468|
|[[:human genes:v:vps54|VPS54]]|0.468|
|[[:human genes:n:nup153|NUP153]]|0.467|
|[[:human genes:v:vps28|VPS28]]|0.467|
|[[:human genes:c:cdc73|CDC73]]|0.467|
|[[:human genes:n:numa1|NUMA1]]|0.467|
|[[:human genes:a:akt1s1|AKT1S1]]|0.466|
|[[:human genes:a:atxn1|ATXN1]]|0.466|
|[[:human genes:z:znf541|ZNF541]]|0.465|
|[[:human genes:r:rps10|RPS10]]|0.465|
|[[:human genes:p:pcf11|PCF11]]|0.465|
|[[:human genes:b:bysl|BYSL]]|0.464|
|[[:human genes:k:kif3c|KIF3C]]|0.464|
|[[:human genes:n:nup133|NUP133]]|0.464|
|[[:human genes:f:fam231c|FAM231C]]|0.464|
|[[:human genes:f:fam231a|FAM231A]]|0.464|
|[[:human genes:r:rps5|RPS5]]|0.464|
|[[:human genes:t:tspy2|TSPY2]]|0.463|
|[[:human genes:g:gosr2|GOSR2]]|0.463|
|[[:human genes:h:hist1h4b|HIST1H4B]]|0.463|
|[[:human genes:f:fam25b|FAM25B]]|0.463|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.461|
|[[:human genes:w:wdr75|WDR75]]|0.461|
|[[:human genes:m:med17|MED17]]|0.461|
|[[:human genes:c:cdt1|CDT1]]|0.46|
|[[:human genes:r:rbbp5|RBBP5]]|0.459|
|[[:human genes:t:tyms|TYMS]]|0.458|
|[[:human genes:r:rrp15|RRP15]]|0.458|
|[[:human genes:p:psmb1|PSMB1]]|0.458|
|[[:human genes:h:hinfp|HINFP]]|0.458|
|[[:human genes:s:slc38a7|SLC38A7]]|0.458|
|[[:human genes:p:plk4|PLK4]]|0.458|
|[[:human genes:p:psmd1|PSMD1]]|0.457|
|[[:human genes:f:fam160a1|FAM160A1]]|0.457|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.457|
|[[:human genes:s:s1pr4|S1PR4]]|0.457|
|[[:human genes:d:ddx47|DDX47]]|0.457|
|[[:human genes:p:pbxip1|PBXIP1]]|0.456|
|[[:human genes:c:ccdc94|CCDC94]]|0.456|
|[[:human genes:r:riok2|RIOK2]]|0.456|
|[[:human genes:p:polr2a|POLR2A]]|0.455|
|[[:human genes:m:mfsd12|MFSD12]]|0.453|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.452|
|[[:human genes:t:tspy1|TSPY1]]|0.452|
|[[:human genes:m:myh7b|MYH7B]]|0.451|
|[[:human genes:s:slc7a6os|SLC7A6OS]]|0.451|
|[[:human genes:r:rps7|RPS7]]|0.451|
|[[:human genes:m:med15|MED15]]|0.45|
|[[:human genes:c:chmp2a|CHMP2A]]|0.45|
|[[:human genes:p:psmb3|PSMB3]]|0.45|
|[[:human genes:c:ctage9|CTAGE9]]|0.449|
|[[:human genes:d:ddx21|DDX21]]|0.449|
|[[:human genes:n:nbpf10|NBPF10]]|0.448|
|[[:human genes:r:rfc1|RFC1]]|0.448|
|[[:human genes:g:gpx4|GPX4]]|0.447|
|[[:human genes:m:mki67ip|MKI67IP]]|0.446|
|[[:human genes:m:mylk3|MYLK3]]|0.446|
|[[:human genes:i:iscu|ISCU]]|0.446|
|[[:human genes:a:atp13a1|ATP13A1]]|0.446|
|[[:human genes:s:snrnp70|SNRNP70]]|0.446|
|[[:human genes:g:golga6b|GOLGA6B]]|0.445|
|[[:human genes:h:hmgcr|HMGCR]]|0.445|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.444|
|[[:human genes:p:prpf19|PRPF19]]|0.444|
|[[:human genes:g:gprin2|GPRIN2]]|0.442|
|[[:human genes:a:akirin2|AKIRIN2]]|0.442|
|[[:human genes:a:acsf2|ACSF2]]|0.441|
|[[:human genes:s:sart1|SART1]]|0.441|
|[[:human genes:u:ubap1|UBAP1]]|0.441|
|[[:human genes:f:fam20a|FAM20A]]|0.441|
|[[:human genes:c:c3orf17|C3orf17]]|0.441|
|[[:human genes:s:scgb1c1|SCGB1C1]]|0.44|
|[[:human genes:n:nup85|NUP85]]|0.439|
|[[:human genes:s:sfpq|SFPQ]]|0.439|
|[[:human genes:c:cwc22|CWC22]]|0.438|
|[[:human genes:g:gbf1|GBF1]]|0.438|
|[[:human genes:s:snip1|SNIP1]]|0.437|
|[[:human genes:c:cmya5|CMYA5]]|0.437|
|[[:human genes:p:pigs|PIGS]]|0.437|
|[[:human genes:c:copb2|COPB2]]|0.437|
|[[:human genes:z:znf655|ZNF655]]|0.436|
|[[:human genes:r:rnf113a|RNF113A]]|0.436|
|[[:human genes:p:polr2l|POLR2L]]|0.435|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.435|
|[[:human genes:n:nol8|NOL8]]|0.434|
|[[:human genes:p:psmd7|PSMD7]]|0.434|
|[[:human genes:c:cacna1a|CACNA1A]]|0.434|
|[[:human genes:s:sult1a4|SULT1A4]]|0.434|
|[[:human genes:s:sult1a3|SULT1A3]]|0.434|
|[[:human genes:m:mms22l|MMS22L]]|0.434|
|[[:human genes:u:usp35|USP35]]|0.434|
|[[:human genes:v:vps52|VPS52]]|0.433|
|[[:human genes:r:rps9|RPS9]]|0.433|
|[[:human genes:n:nfatc4|NFATC4]]|0.433|
|[[:human genes:b:bage3|BAGE3]]|0.432|
|[[:human genes:b:bage|BAGE]]|0.432|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.432|
|[[:human genes:c:cgb2|CGB2]]|0.432|
|[[:human genes:r:ran|RAN]]|0.432|
|[[:human genes:b:bage2|BAGE2]]|0.432|
|[[:human genes:e:exosc8|EXOSC8]]|0.432|
|[[:human genes:i:ints5|INTS5]]|0.432|
|[[:human genes:b:bage4|BAGE4]]|0.432|
|[[:human genes:r:rps28|RPS28]]|0.431|
|[[:human genes:b:bage5|BAGE5]]|0.431|
|[[:human genes:a:art5|ART5]]|0.43|
|[[:human genes:c:cdc45|CDC45]]|0.429|
|[[:human genes:p:psap|PSAP]]|0.429|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.429|
|[[:human genes:t:traip|TRAIP]]|0.429|
|[[:human genes:c:copz1|COPZ1]]|0.429|
|[[:human genes:t:trappc11|TRAPPC11]]|0.428|
|[[:human genes:r:rpl34|RPL34]]|0.428|
|[[:human genes:e:exosc3|EXOSC3]]|0.427|
|[[:human genes:r:rfxank|RFXANK]]|0.427|
|[[:human genes:p:psmc4|PSMC4]]|0.427|
|[[:human genes:t:trim52|TRIM52]]|0.426|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.426|
|[[:human genes:t:taf1|TAF1]]|0.426|
|[[:human genes:x:xrcc6|XRCC6]]|0.426|
|[[:human genes:p:psmc3|PSMC3]]|0.425|
|[[:human genes:i:itga2b|ITGA2B]]|0.425|
|[[:human genes:s:srrt|SRRT]]|0.425|
|[[:human genes:m:mdm2|MDM2]]|0.425|
|[[:human genes:u:usp36|USP36]]|0.424|
|[[:human genes:p:parp3|PARP3]]|0.424|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.424|
|[[:human genes:n:nup54|NUP54]]|0.424|
|[[:human genes:f:fam86b2|FAM86B2]]|0.424|
|[[:human genes:w:wapal|WAPAL]]|0.423|
|[[:human genes:e:exd1|EXD1]]|0.423|
|[[:human genes:m:med29|MED29]]|0.423|
|[[:human genes:s:scaf1|SCAF1]]|0.423|
|[[:human genes:d:dhfr|DHFR]]|0.422|
|[[:human genes:k:krt2|KRT2]]|0.421|
|[[:human genes:p:psmd8|PSMD8]]|0.421|
|[[:human genes:w:wdr87|WDR87]]|0.421|
|[[:human genes:t:topbp1|TOPBP1]]|0.42|
|[[:human genes:f:ftsj3|FTSJ3]]|0.42|
|[[:human genes:c:ctr9|CTR9]]|0.42|
|[[:human genes:p:ppfia4|PPFIA4]]|0.419|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.419|
|[[:human genes:y:yy1|YY1]]|0.419|
|[[:human genes:z:znf574|ZNF574]]|0.419|
|[[:human genes:n:npipb8|NPIPB8]]|0.419|
|[[:human genes:a:atp1a3|ATP1A3]]|0.418|
|[[:human genes:n:nop56|NOP56]]|0.418|
|[[:human genes:h:hist2h3d|HIST2H3D]]|0.418|
|[[:human genes:p:pop1|POP1]]|0.418|
|[[:human genes:a:asf1b|ASF1B]]|0.417|
|[[:human genes:r:rnf121|RNF121]]|0.417|
|[[:human genes:n:ngdn|NGDN]]|0.417|
|[[:human genes:g:gar1|GAR1]]|0.417|
|[[:human genes:p:prkcz|PRKCZ]]|0.416|
|[[:human genes:p:pramef4|PRAMEF4]]|0.416|
|[[:human genes:n:ncapg|NCAPG]]|0.416|
|[[:human genes:f:fbxo5|FBXO5]]|0.415|
|[[:human genes:m:mtch2|MTCH2]]|0.415|
|[[:human genes:t:ttc1|TTC1]]|0.415|
|[[:human genes:a:akap1|AKAP1]]|0.414|
|[[:human genes:b:bid|BID]]|0.414|
|[[:human genes:m:med12|MED12]]|0.413|
|[[:human genes:u:ube2q2l|UBE2Q2L]]|0.413|
|[[:human genes:k:krt78|KRT78]]|0.413|
|[[:human genes:r:rpl9|RPL9]]|0.413|
|[[:human genes:t:tonsl|TONSL]]|0.413|
|[[:human genes:d:dnm2|DNM2]]|0.413|
|[[:human genes:b:brix1|BRIX1]]|0.413|
|[[:human genes:n:nup93|NUP93]]|0.412|
|[[:human genes:n:noc4l|NOC4L]]|0.412|
|[[:human genes:a:arhgef15|ARHGEF15]]|0.412|
|[[:human genes:c:crnkl1|CRNKL1]]|0.412|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.412|
|[[:human genes:n:nol12|NOL12]]|0.412|
|[[:human genes:m:mcoln1|MCOLN1]]|0.412|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.412|
|[[:human genes:e:elmod3|ELMOD3]]|0.411|
|[[:human genes:p:ppp1r10|PPP1R10]]|0.41|
|[[:human genes:h:h3f3a|H3F3A]]|0.41|
|[[:human genes:u:unc13a|UNC13A]]|0.409|
|[[:human genes:c:ckap5|CKAP5]]|0.409|
|[[:human genes:s:sf3b2|SF3B2]]|0.409|
|[[:human genes:b:bms1|BMS1]]|0.409|
|[[:human genes:g:gon4l|GON4L]]|0.409|
|[[:human genes:r:rps3a|RPS3A]]|0.409|
|[[:human genes:s:snrnp200|SNRNP200]]|0.408|
|[[:human genes:p:psmd6|PSMD6]]|0.408|
|[[:human genes:n:nuf2|NUF2]]|0.408|
|[[:human genes:r:rffl|RFFL]]|0.408|
|[[:human genes:g:gnb3|GNB3]]|0.408|
|[[:human genes:x:xab2|XAB2]]|0.407|
|[[:human genes:n:nufip2|NUFIP2]]|0.407|
|[[:human genes:m:mat2a|MAT2A]]|0.407|
|[[:human genes:a:angptl4|ANGPTL4]]|0.406|
|[[:human genes:e:egr2|EGR2]]|0.406|
|[[:human genes:r:rnf4|RNF4]]|0.406|
|[[:human genes:n:nbpf16|NBPF16]]|0.406|
|[[:human genes:p:pole2|POLE2]]|0.406|
|[[:human genes:r:rrp36|RRP36]]|0.405|
|[[:human genes:c:chmp4b|CHMP4B]]|0.405|
|[[:human genes:n:nup98|NUP98]]|0.404|
|[[:human genes:p:plrg1|PLRG1]]|0.404|
|[[:human genes:w:wdr43|WDR43]]|0.404|
|[[:human genes:z:znf148|ZNF148]]|0.404|
|[[:human genes:t:top1mt|TOP1MT]]|0.404|
|[[:human genes:t:ttk|TTK]]|0.404|
|[[:human genes:d:dido1|DIDO1]]|0.404|
|[[:human genes:w:wdr46|WDR46]]|0.404|
|[[:human genes:n:nelfcd|NELFCD]]|0.403|
|[[:human genes:p:plk1|PLK1]]|0.403|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.403|
|[[:human genes:r:rpl27|RPL27]]|0.402|
|[[:human genes:r:rpsa|RPSA]]|0.402|
|[[:human genes:d:ddx56|DDX56]]|0.402|
|[[:human genes:t:tagln|TAGLN]]|0.402|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.401|
|[[:human genes:r:rpl12|RPL12]]|0.401|
|[[:human genes:r:rrm1|RRM1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 632/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|25/28|
|bone|22/25|
|breast|28/33|
|central nervous system|51/56|
|cervix|2/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|18/21|
|liver|19/20|
|lung|55/75|
|lymphocyte|12/14|
|ovary|21/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 287
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHD4 Expression in NALM6 Cells: 9.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>