CHD4

Gene Information

Official Symbol: CHD4
Official Name: chromodomain helicase DNA binding protein 4
Aliases and Previous Symbols: N/A
Entrez ID: 1108
UniProt: Q14839
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
UniProt Summary: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-2.17
B02 10μM R08 exp453	1.7
HMS-I2 1μM R06 exp286	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.74
Isoniazid 100μM R08 exp494	1.77
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.78
S-trityl-L-cysteine 0.5μM R05 exp243	1.78
Alpha-Amanitin 0.5μM R00 exp5	1.89
LB-100 2μM R05 exp210	1.91
UM0011500 10μM R05 exp246	1.92
YM155 0.001μM R08 exp432	2
Rifampicin 30μM R08 exp430	2.03
UM0011500 5μM R05 exp245	2.14

Gene	Correlation
PSMB4	0.632
CBWD3	0.625
TBC1D3G	0.611
MT1E	0.607
TBC1D3H	0.6
CBWD5	0.6
CBWD6	0.599
TCEB3C	0.595
TBC1D3F	0.593
RPS2	0.591
AAMP	0.589
DDTL	0.584
KCTD17	0.583
TCEB3CL2	0.583
TFIP11	0.575
CCNA2	0.575
ORC1	0.572
C1QTNF9B	0.572
SLC4A1	0.572
POLR2D	0.571
PAN3	0.57
SUPT5H	0.569
DISP2	0.568
TCEB3CL	0.568
PSMA6	0.567
COPA	0.567
TICRR	0.566
VASN	0.565
PSMD11	0.565
POLE	0.562
C14orf93	0.561
GID4	0.56
TSG101	0.553
NUPL1	0.552
NOL10	0.549
LRR1	0.548
MYB	0.548
ORC6	0.548
EXOSC9	0.547
CTAGE4	0.546
ZFAND5	0.546
ANKLE2	0.545
POLR2F	0.544
SLC6A17	0.541
RPS12	0.541
ZNF830	0.539
TBC1D3	0.538
TP53TG3B	0.537
PSMC6	0.537
PAN2	0.537
RPL35	0.537
TP53TG3	0.536
TP53TG3C	0.536
SAP30BP	0.535
PAF1	0.534
NPIPB5	0.533
NAPA	0.532
COPG1	0.532
CLN6	0.531
AQR	0.531
EXOSC5	0.529
POLA1	0.528
NARFL	0.528
TBC1D3C	0.528
CACTIN	0.526
PSMD3	0.526
TUBA8	0.525
STIL	0.525
TWISTNB	0.524
COPB1	0.524
MYT1L	0.523
AATF	0.522
LAD1	0.52
POLR1A	0.52
PSMD2	0.519
PSMA7	0.519
RPL6	0.519
IK	0.518
OSBP	0.516
TBC1D3E	0.515
NOP16	0.515
TBC1D3I	0.515
TBC1D3L	0.514
TBC1D3K	0.514
DTL	0.513
PSMC1	0.513
CCDC64B	0.513
HIVEP3	0.513
HIST2H3A	0.512
POLA2	0.511
PSMC5	0.511
BRD2	0.511
HIST2H3C	0.511
RRP7A	0.511
NUP160	0.51
XYLT2	0.51
MED14	0.509
MYO1H	0.508
SYT9	0.508
TP53TG3D	0.506
POLR2J3	0.506
CDH24	0.505
SSH2	0.505
COPE	0.504
RNPC3	0.504
RBM39	0.503
RANBP2	0.503
PSMB2	0.501
SF3A1	0.501
ZNF106	0.5
UPF1	0.499
KIAA0947	0.498
ARCN1	0.498
PSMC2	0.498
COL2A1	0.496
ANKLE1	0.496
SMG7	0.496
SF3A3	0.495
EXOSC6	0.495
SMG1	0.494
DHX38	0.494
TIMELESS	0.492
PRIM1	0.491
TERF1	0.49
KPNB1	0.49
HNRNPC	0.49
OR10G3	0.49
GOLGA6A	0.489
UTP3	0.489
RRN3	0.488
DDT	0.488
RPS20	0.488
SH3BP1	0.488
SMTN	0.488
FBXW9	0.488
ATP6V1C1	0.487
MBTD1	0.486
CCDC116	0.485
UQCRH	0.485
GOLGA6L6	0.483
MADCAM1	0.482
PSMD14	0.481
SUPT6H	0.48
CDCA3	0.48
CEP192	0.48
ATP6V1B2	0.479
ATP6V0C	0.478
TSPY8	0.478
IGFN1	0.478
SEC13	0.477
RPS19BP1	0.477
PWP2	0.476
RPL30	0.475
RAD21	0.475
OGFR	0.475
RAD51	0.475
RPS19	0.474
NUP205	0.474
EXOSC4	0.474
DNTTIP2	0.474
GOLGA8O	0.473
SNRPA1	0.473
ATP6AP1	0.472
MYO18A	0.471
ATP6V1A	0.471
CHAF1A	0.47
HAP1	0.469
CDC6	0.469
DOCK6	0.469
RFPL3	0.469
EBNA1BP2	0.468
NSF	0.468
VPS54	0.468
NUP153	0.467
VPS28	0.467
CDC73	0.467
NUMA1	0.467
AKT1S1	0.466
ATXN1	0.466
ZNF541	0.465
RPS10	0.465
PCF11	0.465
BYSL	0.464
KIF3C	0.464
NUP133	0.464
FAM231C	0.464
FAM231A	0.464
RPS5	0.464
TSPY2	0.463
GOSR2	0.463
HIST1H4B	0.463
FAM25B	0.463
GOLGA6L4	0.461
WDR75	0.461
MED17	0.461
CDT1	0.46
RBBP5	0.459
TYMS	0.458
RRP15	0.458
PSMB1	0.458
HINFP	0.458
SLC38A7	0.458
PLK4	0.458
PSMD1	0.457
FAM160A1	0.457
GOLGA6L3	0.457
S1PR4	0.457
DDX47	0.457
PBXIP1	0.456
CCDC94	0.456
RIOK2	0.456
POLR2A	0.455
MFSD12	0.453
BCL2L1	0.452
TSPY1	0.452
MYH7B	0.451
SLC7A6OS	0.451
RPS7	0.451
MED15	0.45
CHMP2A	0.45
PSMB3	0.45
CTAGE9	0.449
DDX21	0.449
NBPF10	0.448
RFC1	0.448
GPX4	0.447
MKI67IP	0.446
MYLK3	0.446
ISCU	0.446
ATP13A1	0.446
SNRNP70	0.446
GOLGA6B	0.445
HMGCR	0.445
HIST2H2BF	0.444
PRPF19	0.444
GPRIN2	0.442
AKIRIN2	0.442
ACSF2	0.441
SART1	0.441
UBAP1	0.441
FAM20A	0.441
C3orf17	0.441
SCGB1C1	0.44
NUP85	0.439
SFPQ	0.439
CWC22	0.438
GBF1	0.438
SNIP1	0.437
CMYA5	0.437
PIGS	0.437
COPB2	0.437
ZNF655	0.436
RNF113A	0.436
POLR2L	0.435
COX7A2L	0.435
NOL8	0.434
PSMD7	0.434
CACNA1A	0.434
SULT1A4	0.434
SULT1A3	0.434
MMS22L	0.434
USP35	0.434
VPS52	0.433
RPS9	0.433
NFATC4	0.433
BAGE3	0.432
BAGE	0.432
ALDH1B1	0.432
CGB2	0.432
RAN	0.432
BAGE2	0.432
EXOSC8	0.432
INTS5	0.432
BAGE4	0.432
RPS28	0.431
BAGE5	0.431
ART5	0.43
CDC45	0.429
PSAP	0.429
PDE4DIP	0.429
TRAIP	0.429
COPZ1	0.429
TRAPPC11	0.428
RPL34	0.428
EXOSC3	0.427
RFXANK	0.427
PSMC4	0.427
TRIM52	0.426
HIST1H2BE	0.426
TAF1	0.426
XRCC6	0.426
PSMC3	0.425
ITGA2B	0.425
SRRT	0.425
MDM2	0.425
USP36	0.424
PARP3	0.424
ATP6V0B	0.424
NUP54	0.424
FAM86B2	0.424
WAPAL	0.423
EXD1	0.423
MED29	0.423
SCAF1	0.423
DHFR	0.422
KRT2	0.421
PSMD8	0.421
WDR87	0.421
TOPBP1	0.42
FTSJ3	0.42
CTR9	0.42
PPFIA4	0.419
GOLGA6L1	0.419
YY1	0.419
ZNF574	0.419
NPIPB8	0.419
ATP1A3	0.418
NOP56	0.418
HIST2H3D	0.418
POP1	0.418
ASF1B	0.417
RNF121	0.417
NGDN	0.417
GAR1	0.417
PRKCZ	0.416
PRAMEF4	0.416
NCAPG	0.416
FBXO5	0.415
MTCH2	0.415
TTC1	0.415
AKAP1	0.414
BID	0.414
MED12	0.413
UBE2Q2L	0.413
KRT78	0.413
RPL9	0.413
TONSL	0.413
DNM2	0.413
BRIX1	0.413
NUP93	0.412
NOC4L	0.412
ARHGEF15	0.412
CRNKL1	0.412
C2orf27B	0.412
NOL12	0.412
MCOLN1	0.412
ATP6AP2	0.412
ELMOD3	0.411
PPP1R10	0.41
H3F3A	0.41
UNC13A	0.409
CKAP5	0.409
SF3B2	0.409
BMS1	0.409
GON4L	0.409
RPS3A	0.409
SNRNP200	0.408
PSMD6	0.408
NUF2	0.408
RFFL	0.408
GNB3	0.408
XAB2	0.407
NUFIP2	0.407
MAT2A	0.407
ANGPTL4	0.406
EGR2	0.406
RNF4	0.406
NBPF16	0.406
POLE2	0.406
RRP36	0.405
CHMP4B	0.405
NUP98	0.404
PLRG1	0.404
WDR43	0.404
ZNF148	0.404
TOP1MT	0.404
TTK	0.404
DIDO1	0.404
WDR46	0.404
NELFCD	0.403
PLK1	0.403
TGFBRAP1	0.403
RPL27	0.402
RPSA	0.402
DDX56	0.402
TAGLN	0.402
MPHOSPH10	0.401
RPL12	0.401
RRM1	0.4

Global Fraction of Cell Lines Where Essential: 632/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	26/28
blood	25/28
bone	22/25
breast	28/33
central nervous system	51/56
cervix	2/4
colorectal	16/17
esophagus	11/13
fibroblast	1/1
gastric	15/15
kidney	18/21
liver	19/20
lung	55/75
lymphocyte	12/14
ovary	21/26
pancreas	20/24
peripheral nervous system	14/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	6/7
thyroid	2/2
upper aerodigestive	15/22
urinary tract	26/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 287
Expression level (log2 read counts): 9.57

Expression Distribution

ResIII
Chromo
CHDNT
DUF1087
PHD
DUF1086
CHDCT2
HDA2-3
Helicase C
SNF2 N

NuRD complex
RNA polymerase II repressing transcription factor binding
nucleosomal DNA binding
DNA helicase activity
ATP-dependent chromatin remodeling
RNA polymerase II distal enhancer sequence-specific DNA binding
DNA duplex unwinding
histone deacetylase binding
DNA geometric change
chromatin remodeling
regulation of signal transduction by p53 class mediator
nuclear chromatin
DNA conformation change
centrosome
RNA polymerase II proximal promoter sequence-specific DNA binding
protein-containing complex
chromatin organization
zinc ion binding
chromosome organization
DNA binding
ATP binding
regulation of intracellular signal transduction
membrane