PPP1R10

Gene Information

Official Symbol: PPP1R10
Official Name: protein phosphatase 1 regulatory subunit 10
Aliases and Previous Symbols: N/A
Entrez ID: 5514
UniProt: Q96QC0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). {ECO:0000250, ECO:0000269|PubMed:9450550}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Mdivi-1 15μM R05 exp217	1.71
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.72
Methotrexate 0.01μM R08 exp501	1.81
Vinorelbine 0.001μM R05 exp249	1.87
LJH685 50μM R08 exp433	1.88
B02 10μM R08 exp453	1.89
5-Azacytidine 2μM R07 exp330	2.03
MS023 2μM R03 exp134	2.06
UM0011500 10μM R05 exp246	2.24
Diepoxybutane 3μM R07 exp354	2.56

Global Fraction of Cell Lines Where Essential: 558/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	21/28
blood	19/28
bone	21/26
breast	18/33
central nervous system	39/56
cervix	3/4
colorectal	14/17
esophagus	11/13
fibroblast	1/1
gastric	9/16
kidney	14/21
liver	17/20
lung	57/75
lymphocyte	15/16
ovary	18/26
pancreas	19/24
peripheral nervous system	13/16
plasma cell	11/15
prostate	1/1
skin	17/24
soft tissue	6/9
thyroid	0/2
upper aerodigestive	15/22
urinary tract	21/29
uterus	5/5

Essentiality in NALM6

Essentiality Rank: 413
Expression level (log2 read counts): 6.59

Expression Distribution

Gene	Correlation
CCDC84	0.456
SLC6A17	0.418
TCEB3CL	0.414
CHD4	0.41
GOLGA6L1	0.4

negative regulation of mitotic DNA damage checkpoint
regulation of mitotic DNA damage checkpoint
negative regulation of DNA damage checkpoint
negative regulation of cell cycle checkpoint
PTW/PP1 phosphatase complex
regulation of DNA damage checkpoint
negative regulation of cardiac muscle cell apoptotic process
negative regulation of striated muscle cell apoptotic process
regulation of cell cycle checkpoint
protein phosphatase inhibitor activity
regulation of cardiac muscle cell apoptotic process
negative regulation of muscle cell apoptotic process
regulation of striated muscle cell apoptotic process
positive regulation of telomere maintenance
negative regulation of phosphoprotein phosphatase activity
negative regulation of protein dephosphorylation
regulation of muscle cell apoptotic process
negative regulation of response to DNA damage stimulus
regulation of telomere maintenance
protein import into nucleus
negative regulation of phosphatase activity
nuclear chromosome, telomeric region
negative regulation of dephosphorylation
chromatin
import into nucleus
regulation of phosphoprotein phosphatase activity
regulation of protein dephosphorylation
protein import
positive regulation of mitotic cell cycle
protein localization to nucleus
positive regulation of chromosome organization
regulation of phosphatase activity
positive regulation of DNA metabolic process
regulation of dephosphorylation
regulation of response to DNA damage stimulus
nucleocytoplasmic transport
nuclear transport
nuclear body
negative regulation of mitotic cell cycle
negative regulation of cell cycle process