CHGA [The Human Chemical-Genetic Interaction Map Project]

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======= CHGA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHGA
  * **<color #00a2e8>Official Name</color>**: chromogranin A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1113|1113]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10645|P10645]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHGA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHGA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/118910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Granin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation|
|positive regulation of dense core granule biogenesis|
|positive regulation of relaxation of muscle|
|positive regulation of relaxation of cardiac muscle|
|mast cell cytokine production|
|chromaffin granule|
|regulation of dense core granule biogenesis|
|positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|
|protein localization to secretory granule|
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|regulation of phospholipase C-activating G protein-coupled receptor signaling pathway|
|mast cell chemotaxis|
|mast cell migration|
|myeloid leukocyte cytokine production|
|regulation of relaxation of cardiac muscle|
|G protein-coupled receptor signaling pathway involved in heart process|
|regulation of relaxation of muscle|
|positive regulation of cardiac muscle contraction|
|relaxation of cardiac muscle|
|positive regulation of striated muscle contraction|
|negative regulation of catecholamine secretion|
|mast cell degranulation|
|mast cell activation involved in immune response|
|mast cell mediated immunity|
|relaxation of muscle|
|mast cell granule|
|cytokine production involved in immune response|
|mast cell activation|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|negative regulation of amine transport|
|regulation of the force of heart contraction|
|positive regulation of G protein-coupled receptor signaling pathway|
|defense response to fungus|
|negative regulation of insulin secretion|
|positive regulation of heart contraction|
|negative regulation of blood vessel diameter|
|transport vesicle membrane|
|lysosome localization|
|positive regulation of muscle contraction|
|negative regulation of peptide hormone secretion|
|response to fungus|
|killing of cells of other organism|
|disruption of cells of other organism|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|positive regulation of blood circulation|
|regulation of cardiac muscle contraction|
|defense response to Gram-negative bacterium|
|secretory granule|
|cell killing|
|regulation of striated muscle contraction|
|defense response to Gram-positive bacterium|
|regulation of amine transport|
|heart process|
|antimicrobial humoral response|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|myeloid leukocyte migration|
|negative regulation of protein secretion|
|regulation of blood vessel diameter|
|negative regulation of peptide secretion|
|regulation of tube diameter|
|regulation of tube size|
|regulation of G protein-coupled receptor signaling pathway|
|leukocyte chemotaxis|
|cAMP-mediated signaling|
|cytokine production|
|modification of morphology or physiology of other organism|
|regulation of muscle contraction|
|vascular process in circulatory system|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|production of molecular mediator of immune response|
|regulation of blood pressure|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|negative regulation of secretion by cell|
|negative regulation of neuron death|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|regulation of peptide hormone secretion|
|cell chemotaxis|
|negative regulation of secretion|
|regulation of muscle system process|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of hormone secretion|
|regulation of blood circulation|
|muscle system process|
|regulation of neuron death|
|defense response to bacterium|
|second-messenger-mediated signaling|
|humoral immune response|
|establishment of organelle localization|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|leukocyte degranulation|
|regulation of anatomical structure size|
|myeloid leukocyte mediated immunity|
|positive regulation of cellular component biogenesis|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|chemotaxis|
|taxis|
|organelle localization|
|myeloid leukocyte activation|
|regulation of system process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|response to bacterium|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|leukocyte mediated immunity|
|innate immune response|
|exocytosis|
|regulation of secretion|
|interspecies interaction between organisms|
|leukocyte activation|
|defense response to other organism|
|regulation of cellular component biogenesis|
|cell migration|
|negative regulation of cell death|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|secretion|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|intracellular transport|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.72|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atxn1|ATXN1]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1971
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHGA Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>