CHGA
Gene Information
- Official Symbol: CHGA
- Official Name: chromogranin A
- Aliases and Previous Symbols: N/A
- Entrez ID: 1113
- UniProt: P10645
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. {ECO:0000250|UniProtKB:P26339}.
Pfam Domains GO Terms
Pfam Domains
| Granin |
GO Terms
| adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation |
| positive regulation of dense core granule biogenesis |
| positive regulation of relaxation of muscle |
| positive regulation of relaxation of cardiac muscle |
| mast cell cytokine production |
| chromaffin granule |
| regulation of dense core granule biogenesis |
| positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| protein localization to secretory granule |
| adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process |
| regulation of phospholipase C-activating G protein-coupled receptor signaling pathway |
| mast cell chemotaxis |
| mast cell migration |
| myeloid leukocyte cytokine production |
| regulation of relaxation of cardiac muscle |
| G protein-coupled receptor signaling pathway involved in heart process |
| regulation of relaxation of muscle |
| positive regulation of cardiac muscle contraction |
| relaxation of cardiac muscle |
| positive regulation of striated muscle contraction |
| negative regulation of catecholamine secretion |
| mast cell degranulation |
| mast cell activation involved in immune response |
| mast cell mediated immunity |
| relaxation of muscle |
| mast cell granule |
| cytokine production involved in immune response |
| mast cell activation |
| adenylate cyclase-activating adrenergic receptor signaling pathway |
| adrenergic receptor signaling pathway |
| negative regulation of amine transport |
| regulation of the force of heart contraction |
| positive regulation of G protein-coupled receptor signaling pathway |
| defense response to fungus |
| negative regulation of insulin secretion |
| positive regulation of heart contraction |
| negative regulation of blood vessel diameter |
| transport vesicle membrane |
| lysosome localization |
| positive regulation of muscle contraction |
| negative regulation of peptide hormone secretion |
| response to fungus |
| killing of cells of other organism |
| disruption of cells of other organism |
| regulation of catecholamine secretion |
| negative regulation of hormone secretion |
| positive regulation of blood circulation |
| regulation of cardiac muscle contraction |
| defense response to Gram-negative bacterium |
| secretory granule |
| cell killing |
| regulation of striated muscle contraction |
| defense response to Gram-positive bacterium |
| regulation of amine transport |
| heart process |
| antimicrobial humoral response |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| myeloid leukocyte migration |
| negative regulation of protein secretion |
| regulation of blood vessel diameter |
| negative regulation of peptide secretion |
| regulation of tube diameter |
| regulation of tube size |
| regulation of G protein-coupled receptor signaling pathway |
| leukocyte chemotaxis |
| cAMP-mediated signaling |
| cytokine production |
| modification of morphology or physiology of other organism |
| regulation of muscle contraction |
| vascular process in circulatory system |
| cyclic-nucleotide-mediated signaling |
| regulation of insulin secretion |
| production of molecular mediator of immune response |
| regulation of blood pressure |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| negative regulation of secretion by cell |
| negative regulation of neuron death |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of peptide hormone secretion |
| cell chemotaxis |
| negative regulation of secretion |
| regulation of muscle system process |
| regulation of heart contraction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| regulation of hormone secretion |
| regulation of blood circulation |
| muscle system process |
| regulation of neuron death |
| defense response to bacterium |
| second-messenger-mediated signaling |
| humoral immune response |
| establishment of organelle localization |
| leukocyte migration |
| blood circulation |
| circulatory system process |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| leukocyte degranulation |
| regulation of anatomical structure size |
| myeloid leukocyte mediated immunity |
| positive regulation of cellular component biogenesis |
| myeloid cell activation involved in immune response |
| regulation of hormone levels |
| chemotaxis |
| taxis |
| organelle localization |
| myeloid leukocyte activation |
| regulation of system process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| response to bacterium |
| perinuclear region of cytoplasm |
| regulated exocytosis |
| regulation of protein transport |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| leukocyte mediated immunity |
| innate immune response |
| exocytosis |
| regulation of secretion |
| interspecies interaction between organisms |
| leukocyte activation |
| defense response to other organism |
| regulation of cellular component biogenesis |
| cell migration |
| negative regulation of cell death |
| secretion by cell |
| regulation of protein localization |
| export from cell |
| cell activation |
| cell motility |
| localization of cell |
| immune effector process |
| secretion |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| G protein-coupled receptor signaling pathway |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| intracellular transport |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| extracellular space |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| GSK-J4 1.5μM R08 exp441 | -1.77 |
| AICAR 240μM R05 exp211 | -1.72 |
| NFN1 0.1μM R01 exp49 | 2.15 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ATXN1 | 0.425 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1971
- Expression level (log2 read counts): -3.21
Expression Distribution
CHGA Expression in NALM6 Cells: -3.21
