CHN1

Entrez Summary: This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
UniProt Summary: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
TGF-beta1 44ng/ml R08 exp528	1.75
Dimethyloxaloylglycine 11μM R07 exp314	1.77
Chloramphenicol 20μM R00 exp13	1.86
Nocodazole 0.02μM R00 exp23	1.87

motor neuron axon guidance
ephrin receptor binding
SH3/SH2 adaptor activity
ephrin receptor signaling pathway
regulation of axonogenesis
axon guidance
neuron projection guidance
GTPase activator activity
regulation of cell morphogenesis involved in differentiation
regulation of small GTPase mediated signal transduction
axonogenesis
axon development
positive regulation of GTPase activity
cell morphogenesis involved in neuron differentiation
neuron projection morphogenesis
regulation of GTPase activity
plasma membrane bounded cell projection morphogenesis
regulation of cell morphogenesis
cell projection morphogenesis
regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
cell part morphogenesis
chemotaxis
taxis
cell morphogenesis involved in differentiation
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
enzyme linked receptor protein signaling pathway
cell morphogenesis
positive regulation of hydrolase activity
neuron development
regulation of neurogenesis
cellular component morphogenesis
regulation of nervous system development
regulation of cell development
neuron differentiation
regulation of anatomical structure morphogenesis
plasma membrane bounded cell projection organization