CHP2 [The Human Chemical-Genetic Interaction Map Project]

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======= CHP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHP2
  * **<color #00a2e8>Official Name</color>**: calcineurin like EF-hand protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63928|63928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43745|O43745]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269|PubMed:12226101, ECO:0000269|PubMed:18815128}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of calcineurin-mediated signaling|
|positive regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|positive regulation of phosphatase activity|
|regulation of calcineurin-NFAT signaling cascade|
|positive regulation of protein import into nucleus|
|positive regulation of protein import|
|positive regulation of calcium-mediated signaling|
|regulation of protein import into nucleus|
|positive regulation of dephosphorylation|
|regulation of protein import|
|positive regulation of nucleocytoplasmic transport|
|positive regulation of protein localization to nucleus|
|cellular response to calcium ion|
|regulation of calcium-mediated signaling|
|regulation of nucleocytoplasmic transport|
|regulation of protein localization to nucleus|
|response to calcium ion|
|positive regulation of intracellular protein transport|
|regulation of phosphatase activity|
|cellular response to metal ion|
|positive regulation of intracellular transport|
|regulation of dephosphorylation|
|cellular response to inorganic substance|
|regulation of intracellular protein transport|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|response to metal ion|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|response to inorganic substance|
|regulation of cellular protein localization|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|positive regulation of hydrolase activity|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.08|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13566
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHP2 Expression in NALM6 Cells: 3.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>