CHP2

Gene Information

Official Symbol: CHP2
Official Name: calcineurin like EF-hand protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 63928
UniProt: O43745
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. {ECO:0000269|PubMed:12226101, ECO:0000269|PubMed:18815128}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13566
Expression level (log2 read counts): 3.56

Expression Distribution

Screen	Score
Ribavirin 10μM R01 exp52	-2.08
ETC-159 50μM R08 exp480	1.72

positive regulation of calcineurin-mediated signaling
positive regulation of calcineurin-NFAT signaling cascade
regulation of calcineurin-mediated signaling
positive regulation of phosphatase activity
regulation of calcineurin-NFAT signaling cascade
positive regulation of protein import into nucleus
positive regulation of protein import
positive regulation of calcium-mediated signaling
regulation of protein import into nucleus
positive regulation of dephosphorylation
regulation of protein import
positive regulation of nucleocytoplasmic transport
positive regulation of protein localization to nucleus
cellular response to calcium ion
regulation of calcium-mediated signaling
regulation of nucleocytoplasmic transport
regulation of protein localization to nucleus
response to calcium ion
positive regulation of intracellular protein transport
regulation of phosphatase activity
cellular response to metal ion
positive regulation of intracellular transport
regulation of dephosphorylation
cellular response to inorganic substance
regulation of intracellular protein transport
positive regulation of cellular protein localization
regulation of intracellular transport
response to metal ion
positive regulation of protein transport
positive regulation of establishment of protein localization
response to inorganic substance
regulation of cellular protein localization
regulation of protein transport
calcium ion binding
regulation of peptide transport
regulation of establishment of protein localization
positive regulation of hydrolase activity
positive regulation of cell population proliferation
regulation of cellular localization
positive regulation of transport