CHPF

Entrez Summary: N/A
UniProt Summary: Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress. {ECO:0000269|PubMed:12761225}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
chondroitin sulfate biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
chondroitin sulfate proteoglycan metabolic process
proteoglycan biosynthetic process
proteoglycan metabolic process
Golgi cisterna membrane
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
sulfur compound biosynthetic process
glycoprotein biosynthetic process
sulfur compound metabolic process
mitochondrial matrix
glycoprotein metabolic process
Golgi membrane
carbohydrate derivative biosynthetic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process