CHRD [The Human Chemical-Genetic Interaction Map Project]

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======= CHRD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CHRD
  * **<color #00a2e8>Official Name</color>**: chordin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8646|8646]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2X0|Q9H2X0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CHRD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CHRD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603475|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|CHRD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|BMP signaling pathway involved in spinal cord dorsal/ventral patterning|
|floor plate development|
|syndecan binding|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|positive regulation of mesenchymal cell proliferation|
|gastrulation with mouth forming second|
|regulation of mesenchymal cell proliferation|
|cytokine binding|
|negative regulation of osteoblast differentiation|
|negative regulation of BMP signaling pathway|
|mesoderm formation|
|mesoderm morphogenesis|
|negative regulation of ossification|
|dorsal/ventral pattern formation|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|spinal cord development|
|formation of primary germ layer|
|regulation of osteoblast differentiation|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|mesoderm development|
|osteoblast differentiation|
|negative regulation of cellular response to growth factor stimulus|
|gastrulation|
|neural tube development|
|heparin binding|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of cell migration|
|ossification|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regionalization|
|forebrain development|
|positive regulation of cell adhesion|
|pattern specification process|
|skeletal system development|
|cellular response to growth factor stimulus|
|response to growth factor|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|epithelium development|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.92|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.83|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.72|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11233
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CHRD Expression in NALM6 Cells: 1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>