CHRD

Entrez Summary: This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

VWC
CHRD

BMP signaling pathway involved in spinal cord dorsal/ventral patterning
floor plate development
syndecan binding
spinal cord dorsal/ventral patterning
spinal cord patterning
positive regulation of mesenchymal cell proliferation
gastrulation with mouth forming second
regulation of mesenchymal cell proliferation
cytokine binding
negative regulation of osteoblast differentiation
negative regulation of BMP signaling pathway
mesoderm formation
mesoderm morphogenesis
negative regulation of ossification
dorsal/ventral pattern formation
regulation of BMP signaling pathway
BMP signaling pathway
cellular response to BMP stimulus
response to BMP
spinal cord development
formation of primary germ layer
regulation of osteoblast differentiation
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
mesoderm development
osteoblast differentiation
negative regulation of cellular response to growth factor stimulus
gastrulation
neural tube development
heparin binding
regulation of ossification
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of cell migration
ossification
regulation of cellular response to growth factor stimulus
negative regulation of cell motility
negative regulation of cellular component movement
negative regulation of locomotion
regionalization
forebrain development