CHRM1
Gene Information
- Official Symbol: CHRM1
- Official Name: cholinergic receptor muscarinic 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1128
- UniProt: P11229
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential |
| phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| saliva secretion |
| G protein-coupled acetylcholine receptor activity |
| adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway |
| cholinergic synapse |
| G protein-coupled acetylcholine receptor signaling pathway |
| secretion by tissue |
| phosphatidylinositol phospholipase C activity |
| protein kinase C-activating G protein-coupled receptor signaling pathway |
| regulation of glial cell proliferation |
| acetylcholine receptor signaling pathway |
| response to acetylcholine |
| cellular response to acetylcholine |
| neuromuscular synaptic transmission |
| G protein-coupled serotonin receptor activity |
| G protein-coupled serotonin receptor signaling pathway |
| neurotransmitter receptor activity |
| postsynaptic signal transduction |
| serotonin receptor signaling pathway |
| integral component of postsynaptic density membrane |
| axon terminus |
| integral component of presynaptic membrane |
| digestive system process |
| body fluid secretion |
| Schaffer collateral - CA1 synapse |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| cellular response to dopamine |
| response to dopamine |
| signal transduction involved in cellular response to ammonium ion |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of postsynaptic membrane potential |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to catecholamine |
| response to monoamine |
| digestion |
| regulation of gliogenesis |
| cellular response to ammonium ion |
| positive regulation of intracellular protein transport |
| response to ammonium ion |
| positive regulation of intracellular transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of intracellular protein transport |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of ion transport |
| cognition |
| positive regulation of cellular protein localization |
| glutamatergic synapse |
| regulation of intracellular transport |
| cellular response to drug |
| dendrite |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| positive regulation of protein transport |
| regulation of membrane potential |
| trans-synaptic signaling |
| positive regulation of establishment of protein localization |
| synaptic signaling |
| regulation of body fluid levels |
| regulation of cellular protein localization |
| cellular response to organic cyclic compound |
| cell junction |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| regulation of ion transport |
| regulation of protein transport |
| G protein-coupled receptor activity |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of neurogenesis |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| regulation of locomotion |
| positive regulation of transport |
| response to organonitrogen compound |
| response to drug |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell-cell signaling |
| secretion |
| cellular response to endogenous stimulus |
| G protein-coupled receptor signaling pathway |
| nervous system process |
| integral component of plasma membrane |
| response to endogenous stimulus |
| generation of neurons |
| response to oxygen-containing compound |
| regulation of cell population proliferation |
| neurogenesis |
| regulation of cell differentiation |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Pyridostatin 4μM R05 exp240 | 1.78 |
| Tubastatin-A 2.5μM R07 exp417 | 1.79 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10595
- Expression level (log2 read counts): -5.01
Expression Distribution
CHRM1 Expression in NALM6 Cells: -5.01
