CHRM5

Entrez Summary: N/A
UniProt Summary: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of phosphatidylinositol dephosphorylation
G protein-coupled acetylcholine receptor activity
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
gastric acid secretion
dopamine transport
catecholamine transport
G protein-coupled acetylcholine receptor signaling pathway
monoamine transport
phosphatidylinositol phospholipase C activity
acetylcholine receptor signaling pathway
cellular response to acetylcholine
response to acetylcholine
G protein-coupled serotonin receptor signaling pathway
G protein-coupled serotonin receptor activity
neurotransmitter receptor activity
serotonin receptor signaling pathway
postsynaptic signal transduction
ammonium transport
transmission of nerve impulse
digestive system process
acid secretion
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of phospholipid metabolic process
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to monoamine
response to catecholamine
digestion
cellular response to ammonium ion
multicellular organismal signaling
organic hydroxy compound transport
drug transport
response to ammonium ion
postsynaptic membrane
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of dephosphorylation
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger