CHRNB4

Entrez Summary: N/A
UniProt Summary: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan LBD
Neur chan memb

synaptic transmission involved in micturition
positive regulation of transmission of nerve impulse
behavioral response to nicotine
micturition
cholinergic synapse
ligand-gated ion channel activity
acetylcholine receptor activity
acetylcholine-gated cation-selective channel activity
acetylcholine-gated channel complex
acetylcholine binding
regulation of transmission of nerve impulse
synaptic transmission, cholinergic
neuromuscular synaptic transmission
excretion
extracellular ligand-gated ion channel activity
response to nicotine
smooth muscle contraction
regulation of smooth muscle contraction
excitatory postsynaptic potential
positive regulation of nervous system process
chemical synaptic transmission, postsynaptic
tertiary granule membrane
specific granule membrane
action potential
regulation of postsynaptic membrane potential
regulation of neurotransmitter secretion
protein heterooligomerization
renal system process
regulation of nervous system process
regulation of neurotransmitter transport
adult behavior
regulation of muscle contraction
locomotory behavior
postsynaptic membrane
regulation of muscle system process
muscle contraction
synapse
muscle system process
neuron projection
regulation of neurotransmitter levels