CHST1

Entrez Summary: This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011].
UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. {ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Golgicide-A 2μM R03 exp121	1.75
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	1.89

keratan sulfotransferase activity
N-acetylglucosamine 6-O-sulfotransferase activity
galactose metabolic process
N-acetylglucosamine metabolic process
glucosamine-containing compound metabolic process
keratan sulfate biosynthetic process
sulfotransferase activity
keratan sulfate metabolic process
amino sugar metabolic process
polysaccharide metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
glycosaminoglycan metabolic process
hexose metabolic process
aminoglycan metabolic process
trans-Golgi network
sulfur compound biosynthetic process
monosaccharide metabolic process
sulfur compound metabolic process
carbohydrate metabolic process
inflammatory response
Golgi membrane
carbohydrate derivative biosynthetic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
defense response
organonitrogen compound biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process