CIC [The Human Chemical-Genetic Interaction Map Project]

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======= CIC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIC
  * **<color #00a2e8>Official Name</color>**: capicua transcriptional repressor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23152|23152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RK0|Q96RK0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CIC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CIC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612082|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HMG box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lung alveolus development|
|intraspecies interaction between organisms|
|social behavior|
|multi-organism behavior|
|memory|
|learning|
|lung development|
|respiratory tube development|
|respiratory system development|
|learning or memory|
|cognition|
|chromatin binding|
|behavior|
|protein-containing complex|
|intracellular membrane-bounded organelle|
|brain development|
|head development|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|central nervous system development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.29|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-2.28|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2.06|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.05|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.03|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.99|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.96|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.94|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.94|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.82|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.77|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.72|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.71|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.7|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.71|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.77|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.84|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.91|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5834
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CIC Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>