CIC

Entrez Summary: The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015].
UniProt Summary: Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development. {ECO:0000250|UniProtKB:Q924A2}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.005μM R00 exp6	-2.29
Phenformin 20μM R05 exp212	-2.28
GW501516 25μM R06 exp285	-2.06
S-trityl-L-cysteine 0.5μM R05 exp243	-2.05
TRAIL 5ng/ml R00 exp35	-2.03
Rapamycin 10μM R00 exp30	-1.99
Campthothecin 0.001μM R06 exp270	-1.96
HMS-I2 1μM R06 exp286	-1.94
Lead acetate 2000μM R08 exp498 no dilution day6	-1.94
Citral 75μM R06 exp275	-1.82
All-trans-Retinoic-Acid 40μM R07 exp334	-1.77
GSK626616 14μM R08 exp485	-1.77
Rapamycin 1μM R00 exp29	-1.72
Vincristine 0.0005μM R04 exp190	-1.71
Ethambutol 25μM R08 exp481	-1.7
Palbociclib 1μM R07 exp382	1.71
Ibrutinib 1μM R07 exp372	1.77
Ribavirin 10μM R01 exp52	1.84
BVD-523 15μM R02 exp67	1.91
Beta-Estradiol 0.55μM R07 exp425	2.06

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lung alveolus development
intraspecies interaction between organisms
social behavior
multi-organism behavior
memory
learning
lung development
respiratory tube development
respiratory system development
learning or memory
cognition
chromatin binding
behavior
protein-containing complex
intracellular membrane-bounded organelle
brain development
head development
tube development
negative regulation of transcription by RNA polymerase II
central nervous system development
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
nervous system process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression
system process