CINP [The Human Chemical-Genetic Interaction Map Project]

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======= CINP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CINP
  * **<color #00a2e8>Official Name</color>**: cyclin dependent kinase 2 interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51550|51550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BW66|Q9BW66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CINP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CINP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613362|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA replication|
|cell division|
|DNA repair|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cell cycle|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.02|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.72|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.437|
|[[:human genes:p:pmm2|PMM2]]|0.422|
|[[:human genes:r:rtcb|RTCB]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 442/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|22/28|
|bone|13/26|
|breast|16/33|
|central nervous system|30/56|
|cervix|1/4|
|colorectal|14/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|17/21|
|liver|13/20|
|lung|48/75|
|lymphocyte|12/16|
|ovary|14/26|
|pancreas|18/24|
|peripheral nervous system|13/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|15/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1838
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CINP Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>