CINP

Entrez Summary: N/A
UniProt Summary: Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling. {ECO:0000269|PubMed:16082200, ECO:0000269|PubMed:19889979}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 442/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	13/28
blood	22/28
bone	13/26
breast	16/33
central nervous system	30/56
cervix	1/4
colorectal	14/17
esophagus	7/13
fibroblast	0/1
gastric	7/16
kidney	17/21
liver	13/20
lung	48/75
lymphocyte	12/16
ovary	14/26
pancreas	18/24
peripheral nervous system	13/16
plasma cell	9/15
prostate	1/1
skin	11/24
soft tissue	7/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	15/29
uterus	1/5

Expression Distribution

DNA replication
cell division
DNA repair
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle
cellular response to stress
cellular macromolecule biosynthetic process
macromolecule biosynthetic process