CIRBP

Entrez Summary: N/A
UniProt Summary: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

small ribosomal subunit rRNA binding
translation repressor activity
stress granule assembly
positive regulation of mRNA splicing, via spliceosome
poly(U) RNA binding
positive regulation of mRNA processing
positive regulation of RNA splicing
mRNA stabilization
RNA stabilization
response to cold
negative regulation of mRNA catabolic process
negative regulation of RNA catabolic process
cytoplasmic stress granule
mRNA 3-UTR binding
positive regulation of mRNA metabolic process
negative regulation of mRNA metabolic process
spliceosomal complex
regulation of mRNA splicing, via spliceosome
positive regulation of translation
negative regulation of translation
regulation of RNA splicing
regulation of mRNA processing
response to UV
negative regulation of cellular amide metabolic process
positive regulation of cellular amide metabolic process
ribonucleoprotein complex
response to temperature stimulus
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
negative regulation of cellular catabolic process
response to light stimulus
negative regulation of catabolic process
regulation of mRNA metabolic process
regulation of translation
regulation of cellular amide metabolic process
response to radiation
ribonucleoprotein complex biogenesis